Abstract Phospholipase A2 (PLA2) catalyses the release of arachidonic acid for generation
of lipid mediators of inflammation and is crucial in diverse inflammatory processes. The …

Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway
inflammation and remodeling in asthma. The availability of free arachidonate in cells for …

Among the emerging phospholipase A2 (PLA2) superfamily, the secreted PLA2 (sPLA2)
family consists of low-molecular-mass, Ca2+-requiring extracellular enzymes with a His-Asp …

Les cellules de mammifères ont acquis des voies spécifiques pour l'incorporation, la
redistribution et la libération de l'acide arachidonique. Les voies de l'acyltransférase et de la …

Activation of macrophages and macrophage cell lines by bacterial LPS elicits a delayed
phase of PG biosynthesis that appears to be entirely mediated by cyclooxygenase-2 (COX …

Stable expression of human groups IIA and X secreted phospholipases A 2 (hGIIA and hGX)
in CHO-K1 and HEK293 cells leads to serum-and interleukin-1β-promoted arachidonate …

In murine P388D 1 macrophages, the generation of prostaglandin E 2 in response to long
term stimulation by lipopolysaccharide involves the action of Group V secreted …

Gelsolin is a highly conserved, multifunctional actin-binding protein initially described in the
cytosol of macrophages and subsequently identified in many vertebrate cells. A unique …

Leukotriene A4 hydrolase (LTA4H) is a bifunctional zinc enzyme with the activities of
epoxide hydrolase and aminopeptidase. As an epoxide hydrolase, LTA4H catalyzes the …

Considerable progress has been made in characterizing the individual participant enzymes
and their relative contributions in the generation of eicosanoids, lipid mediators derived from …