Introduction The secretory phospholipase A 2 (sPLA 2) family provides a seemingly endless
array of potential biological functions that is only beginning to be appreciated. In humans …

Secretory phospholipases A2 (sPLA2s) are molecules released in plasma and biologic
fluids of patients with systemic inflammatory, autoimmune, and allergic diseases. Several …

Secretory phospholipase A2 (sPLA2) is a growing family of structurally related, disulfide-rich,
low molecular weight, lipolytic enzymes with a His-Asp catalytic dyad. sPLA2s are …

In an effort to elucidate the functions of secreted phospholipase A 2 (sPLA 2) enzymes in
vivo, we generated transgenic (Tg) mice for group V sPLA 2 (sPLA 2-V) and group X sPLA 2 …

Secreted phospholipases A2 (sPLA2s) are enzymes detected in serum and biological fluids
of patients with various inflammatory, autoimmune and allergic disorders. Different isoforms …

Phospholipase-A2 (PLA2) enzymes hydrolyze cell membrane phospholipids to produce
arachidonic acid (AA) and lyso-phospholipids (LysoPL), playing a key role in the production …

Objectives: The purpose of this study was to investigate the effects of varespladib on
cardiovascular biomarkers in acute coronary syndrome patients. Background: Secretory …

For membrane-associated enzymes, which access substrate from either a monolayer or
bilayer of the aggregate substrate, the partitioning from the aqueous phase to this …

Abstract Secretory phospholipase A 2 (sPLA 2) represents a class of enzymes that hydrolyze
phospholipids from cellular membranes and lipoproteins, resulting in multifarious …

Human groups IIA, V and X secretory phospholipases A2 (sPLA2s) were incubated with
human HDL3, total HDL and LDL over a range of enzyme and substrate concentrations and …