Here we report cellular arachidonate (AA) release and prostaglandin (PG) production by
novel classes of secretory phospholipase A 2 s (sPLA 2 s), groups III and XII. Human group …

In rat mesangial cells, exogenously added secreted phospholipases A 2 (sPLA 2 s)
potentiate the expression of pro-inflammatory sPLA 2-IIA first induced by cytokines like tumor …

The highly orchestrated transcriptional and metabolic reprogramming during activation
drastically transforms the main functions and physiology of human macrophages across the …

Mast cells may be activated through Toll-like receptors (TLRs) for the dose-and time-
dependent release of eicosanoids. However, the signaling mechanisms of TLR-dependent …

The increased morbidity, mortality, and ineffective treatment associated with the
pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive …

Lung endothelial dysfunction is a key feature of acute lung injury (ALI) and clinical acute
respiratory distress syndrome (ARDS). Previous studies have identified the lipid-generating …

Inffammation of the lung marked by excessive recruitment of neutrophils from circulation to
the airway is a common feature among several pathological lung disorders, particularly …

We investigated the regulatory role of 14-kDa secretory group V phospholipase A2
(gVPLA2) in the development of acute lung injury (ALI) and neutrophilic inflammation (NI) …

Although the expression of the prototypic secretory phospholipase A2 (sPLA2), group IIA
(sPLA2-IIA), is known to be up-regulated during inflammation, it remains uncertain if other …

PC-hydrolyzing sPLA 2 isozymes, particularly sPLA 2-V and sPLA 2-X, are attractive
candidates for proatherosclerotic factors that may act in place of sPLA 2-IIA. However, their …