Eicosanoids are potent lipid mediators derived from phospholipase (PL)-released
arachidonic acid (AA) coupled to subsequent metabolism by cyclooxygenase (COX)-1/2 or …

In response to Ca2+ signaling, cytosolic phospholipase A2α (cPLA2α) translocates from the
cytosol to the perinuclear membrane, where downstream eicosanoid-synthetic enzymes …

A new and unnatural type of phospholipids with the head group attached to the 2-position of
the glycerol backbone has been synthesized and shown to be a good substrate for secretory …

Importance of the field: The high risk of recurrent cardiovascular events amongst patients
with cardiovascular disease receiving evidence-based therapies has prompted …

Both secretory and cytosolic phospholipase A2 enzymes have been implicated in the
pathogenesis of arthritis in animal models, but the exact expression patterns of the enzymes …

We examined the mechanism by which secretory group V phospholipase A 2 (gVPLA 2)
secreted from stimulated epithelial cells activates eosinophil adhesion to ICAM-1 surrogate …

Acute lung injury (ALI) is characterized by inflammatory disruption of the alveolar—vascular
barrier, resulting in severe respiratory compromise. Inhibition of the intercellular messenger …

Inducible expression of group IIA secretory phospholipase A 2 (sPLA 2-IIA) by interleukin-1β
(IL-1β) and tumor necrosisfactor-α (TNFα) is under the control of group IVA cytosolicPLA 2 α …

Following the finding that ammodytoxin (Atx), a neurotoxic secreted phospholipase A2
(sPLA2) in snake venom, binds specifically to protein disulfide isomerase (PDI) in vitro we …

The secreted phospholipase A 2 type IIA (Pla2g2a) gene was previously identified as a
modifier of intestinal adenoma multiplicity in Apc Min/+ mice. To determine if intestinal …