Scale matters: the nested human connectome

M Axer, K Amunts - Science, 2022 - science.org
A comprehensive description of how neurons and entire brain regions are interconnected is
fundamental for a mechanistic understanding of brain function and dysfunction …

[HTML][HTML] Connectome 2.0: Developing the next-generation ultra-high gradient strength human MRI scanner for bridging studies of the micro-, meso-and macro …

SY Huang, T Witzel, B Keil, A Scholz, M Davids, P Dietz… - NeuroImage, 2021 - Elsevier
The first phase of the Human Connectome Project pioneered advances in MRI technology
for mapping the macroscopic structural connections of the living human brain through the …

Fusionnet: A deep fully residual convolutional neural network for image segmentation in connectomics

TM Quan, DGC Hildebrand, WK Jeong - Frontiers in Computer …, 2021 - frontiersin.org
Cellular-resolution connectomics is an ambitious research direction with the goal of
generating comprehensive brain connectivity maps using high-throughput, nano-scale …

A petascale automated imaging pipeline for mapping neuronal circuits with high-throughput transmission electron microscopy

W Yin, D Brittain, J Borseth, ME Scott, D Williams… - Nature …, 2020 - nature.com
Electron microscopy (EM) is widely used for studying cellular structure and network
connectivity in the brain. We have built a parallel imaging pipeline using transmission …

[HTML][HTML] Post mortem mapping of connectional anatomy for the validation of diffusion MRI

A Yendiki, M Aggarwal, M Axer, AFD Howard… - NeuroImage, 2022 - Elsevier
Diffusion MRI (dMRI) is a unique tool for the study of brain circuitry, as it allows us to image
both the macroscopic trajectories and the microstructural properties of axon bundles in vivo …

Linking scientific instruments and computation: Patterns, technologies, and experiences

R Vescovi, R Chard, ND Saint, B Blaiszik, J Pruyne… - Patterns, 2022 - cell.com
Powerful detectors at modern experimental facilities routinely collect data at multiple GB/s.
Online analysis methods are needed to enable the collection of only interesting subsets of …

Preparation of large biological samples for high-resolution, hierarchical, synchrotron phase-contrast tomography with multimodal imaging compatibility

J Brunet, CL Walsh, WL Wagner, A Bellier, C Werlein… - Nature protocols, 2023 - nature.com
Imaging across different scales is essential for understanding healthy organ morphology
and pathophysiological changes. The macro-and microscale three-dimensional morphology …

Linking brain structure, activity, and cognitive function through computation

K Amunts, J DeFelipe, C Pennartz, A Destexhe… - Eneuro, 2022 - eneuro.org
Understanding the human brain is a “Grand Challenge” for 21st century research.
Computational approaches enable large and complex datasets to be addressed efficiently …

[HTML][HTML] Advances and opportunities in high-throughput small-scale mechanical testing

DS Gianola, NM della Ventura, GH Balbus… - Current Opinion in Solid …, 2023 - Elsevier
The quest for novel materials used in technologies demanding extreme performance has
been accelerated by advances in computational materials screening, additive manufacturing …

Double cones and the diverse connectivity of photoreceptors and bipolar cells in an avian retina

A Günther, K Dedek, S Haverkamp, S Irsen… - Journal of …, 2021 - Soc Neuroscience
Double cones are the most common photoreceptor cell type in most avian retinas, but their
precise functions remain a mystery. Among their suggested functions are luminance …