Molecularly targeted therapies are rapidly growing with respect to their clinical development
and impact on cancer treatment due to their highly selective anti-tumor action. However …

Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising
strategy to combat these age-related diseases by targeting specific antigens and inducing …

Tumor-associated macrophages (TAMs) are key orchestrators of the tumor
microenvironment directly affecting neoplastic cell growth, neoangiogenesis, and …

In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB
(glycoprotein nonmetastatic B) was profoundly upregulated in macrophages interacting with …

Alzheimer's disease (AD) is an irreversible, devastating neurodegenerative brain disorder
characterized by the loss of neurons and subsequent cognitive decline. Despite …

Purpose: Although the murine orthologue of glycoprotein nonmetastatic B (GPNMB),
Osteoactivin, promotes breast cancer metastasis in an in vivo mouse model, its importance …

The skeleton is a preferred site of metastasis in patients with disseminated breast cancer.
We have used 4T1 mouse mammary carcinoma cells, which metastasize to bone from the …

Amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disease
characterized by the loss of motor neurons. Despite substantial research, the causes of ALS …

The skeleton serves as an internal structural support system for vertebrates. It has
mechanisms to grow and change in shape and size to suit varying stressors including the …

Osteoactivin (OA) is a novel glycoprotein that is highly expressed during osteoblast
differentiation. Using Western blot analysis, our data show that OA protein has two isoforms …