Leptin, an adipokine that is implicated in the control of food intake via appetite suppression,
may also stimulate oxidative stress, inflammation, thrombosis, arterial stiffness …

Premature cardiovascular disease (CVD), including stroke, peripheral vascular disease,
sudden death, coronary artery disease, and congestive heart failure, is a notorious problem …

Excess adiposity can induce adverse sequelae in multiple cell types and organ systems.
The transition from the lean to the obese state is characterized by fundamental cellular …

The seemingly counterintuitive risk factor paradox is the hallmark of chronic disease states
or conditions associated with wasting disease at the population level. Studying similarities …

Results There were no clinically significant differences in baseline characteristics between
those who had measured uric acid (n= 4637) and those who did not (n= 1190). Uric acid …

Obesity is a disease which leads to the development of many other disorders. Excessive
accumulation of lipids in adipose tissue (AT) leads to metabolic changes, including …

Chronic kidney disease is among the fastest growing causes of death worldwide. An
increased risk of all-cause and cardiovascular death is thought to depend on the …

Background. Elevated macrophage inhibitory cytokine-1 (MIC-1/GDF15) levels in serum
mediate anorexia and weight loss in some cancer patients and similarly elevated levels …

Pulmonary hypertension (PH) is highly prevalent in end-stage renal disease. Several
observational studies, based on an echocardiographic diagnosis of PH, have suggested a …

Leptin is a product of the obese (OB) gene secreted by adipocytes in proportion to fat mass.
It decreases food intake and increases energy expenditure by affecting the balance between …