The International Human Genome Sequencing Consortium (IHGSC) used a hierarchical
mapping and sequencing strategy to construct the working draft of the human genome. This …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

We describe a new computer system, called ARACHNE, for assembling genome sequence
using paired-end whole-genome shotgun reads. ARACHNE has several key features …

The use of ionizing radiation for the treatment of cancer dates back to the late 19th century,
remarkably soon after Roentgen described X-rays in 1895 and the use of brachytherapy …

Long non-coding RNAs (lncRNAs) are a large and diverse group of RNAs that are often
lineage-specific and that regulate multiple biological functions. Many are nuclear and are …

In yeast, telomere position effect (TPE) results in the reversible silencing of genes near
telomeres. Here we demonstrate the presence of TPE in human cells. HeLa clones …

The 22q11. 2 deletion syndrome, which includes DiGeorge and velocardiofacial syndromes
(DGS/VCFS), is the most common microdeletion syndrome. The majority of deleted patients …

Abstract Spinocerebellar ataxia type 10 (SCA10; MIM 603516; refs 1, 2) is an autosomal
dominant disorder characterized by cerebellar ataxia and seizures. The gene SCA10 maps …

Background The core promoter, a region of about 100 base-pairs flanking the transcription
start site (TSS), serves as the recognition site for the basal transcription apparatus …

The DNA amount in the unreplicated haploid nucleus of an organism is known as its C-
value. C-values differ about 1000-fold among angiosperms and are characteristic of taxa …