Human chromosome 7 has historically received prominent attention in the human genetics
community, primarily related to the search for the cystic fibrosis gene and the frequent …

Traditional approaches for gene mapping from candidate gene studies to positional cloning
strategies have been applied for Mendelian disorders. Since 2005, next-generation …

Vertebrate genomic DNA is generally CpG depleted 1, 2, possibly because methylation of
cytosines at 80% of CpG dinucleotides results in their frequent mutation to thymine, and thus …

As a first step towards a more comprehensive functional characterization of cDNAs than
bioinformatic analysis, which can only make functional predictions for about half of the …

More than 30 organisms have been sequenced entirely. Here, we applied a variety of simple
bioinformatics tools to analyze 29 proteomes for representatives from all three kingdoms …

The centriole and basal body (CBB) structure nucleates cilia and flagella, and is an essential
component of the centrosome, underlying eukaryotic microtubule-based motility, cell division …

The most important product of the sequencing of a genome is a complete, accurate
catalogue of genes and their products, primarily messenger RNA transcripts and their …

Structural genomics has the goal of obtaining useful, three-dimensional models of all
proteins by a combination of experimental structure determination and comparative model …

The number of protein-coding genes in an organism provides a useful first measure of its
molecular complexity. Single-celled prokaryotes and eukaryotes typically have a few …

Development of higher rates of nondiabetic glomerulosclerosis (GS) in African Americans
has been attributed to two coding sequence variants (G1 and G2) in the APOL1 gene. To …