Phytochemicals gained considerable interest during the past years as source to develop
new treatment options for chemoprevention and cancer therapy. Motivated by the fact that a …

The naphthoquinone shikonin is the main active principle of Zicao, a traditional Chinese
herbal medicine made from the dried root of Lithospermum erythrorhizon. Studies carried …

Guanosine triphosphate binding protein 4 (GTPBP4) is a key regulator of cell cycle
progression and MAPK activation. However, how its biological properties intersect with …

Cancer stem cells (CSCs) are responsible for aggressive tumor growth, metastasis and
therapy resistance. In this study, we evaluated the effects of Shikonin (Shk) on breast cancer …

Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for
treatment of depression and other neurological disorders. Evidence has suggested that …

Background Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are the most
common diseases of human digestive system. Nowadays, the influence of the inflammatory …

Naturally occurring naphthoquinones, usually in forms of botanical extracts, have been
implicated with human life since ancient time, far earlier than their isolation and identification …

Shikonin is a natural compound isolated from herbs and traditional medicines that have
been used in a number of countries to treat various illnesses including inflammation, virus …

Pyrrolizidine alkaloids (PAs) are distributed in plant families of Asteraceae, Boraginaceae,
and Fabaceae and serve in the chemical defense mechanism against herbivores. However …

There is a drought of new antibacterial compounds that exploit novel targets. Thioredoxin
reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has …