[HTML][HTML] Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn's disease, and celiac disease

T Braun, KE Sosnovski, A Amir, M BenShoshan… - JCI insight, 2023 - ncbi.nlm.nih.gov
Abstract Ulcerative colitis (UC), Crohn's disease (CD), and celiac disease are prevalent
intestinal inflammatory disorders with nonsatisfactory therapeutic interventions. Analyzing …

CD4+ T cells in HIV: A Friend or a Foe?

S Govindaraj, H Babu, S Kannanganat… - Frontiers in …, 2023 - frontiersin.org
Currently, there are approximately 38.4 million individuals living with the Human
Immunodeficiency Virus (HIV), of which 36.7 million adults, 1.7 million children (< 15 years …

[HTML][HTML] Long noncoding RNA ABHD11-AS1 interacts with SART3 and regulates CD44 RNA alternative splicing to promote lung carcinogenesis

PS Wang, Z Liu, O Sweef, J Xie, J Chen, H Zhu… - Environment …, 2024 - Elsevier
Abstract Hexavalent chromium [Cr (VI)] is a common environmental pollutant and chronic
exposure to Cr (VI) causes lung cancer in humans, however, the mechanism of Cr (VI) …

Exploring the roles of RNAs in chromatin architecture using deep learning

S Kuang, KS Pollard - Nature Communications, 2024 - nature.com
Recent studies have highlighted the impact of both transcription and transcripts on 3D
genome organization, particularly its dynamics. Here, we propose a deep learning …

The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

BG Dogaru, C Munteanu - International Journal of Molecular Sciences, 2023 - mdpi.com
This review explores the emerging role of hydrogen sulfide (H2S) in modulating epigenetic
mechanisms involved in neurodegenerative diseases. Accumulating evidence has begun to …

[HTML][HTML] Post-transcriptional and translational regulation of plant gene expression by transposons

Q Kan, Q Li - Current Opinion in Plant Biology, 2023 - Elsevier
Transposons are mobile DNA sequences that can move within the genome and integrate in
new genomic locations. They are widespread in eukaryotes and prokaryotes and can …

Imprinted long non-coding RNAs in mammalian development and disease

F Di Michele, I Chillón, R Feil - International Journal of Molecular …, 2023 - mdpi.com
Imprinted genes play diverse roles in mammalian development, homeostasis, and disease.
Most imprinted chromosomal domains express one or more long non-coding RNAs …

Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development

J Dave, V Jagana, R Janostiak, M Bisserier - Journal of Translational …, 2023 - Springer
Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …

Molecular mechanism of lncRNAs in pathogenesis and diagnosis of auto-immune diseases, with a special focus on lncRNA-based therapeutic approaches

A Mehmandar-Oskuie, K Jahankhani, A Rostamlou… - Life Sciences, 2023 - Elsevier
Autoimmune diseases are a diverse set of conditions defined by organ damage due to
abnormal innate and acquired immune system responses. The pathophysiology of …

Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer

A Alaimo, S Genovesi, N Annesi, D De Felice… - The EMBO …, 2024 - embopress.org
Inflammation is a common condition of prostate tissue, whose impact on carcinogenesis is
highly debated. Microbial colonization is a well-documented cause of a small percentage of …