[HTML][HTML] Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19

T Lu, R Ma, W Dong, KY Teng, DS Kollath, Z Li… - Nature …, 2022 - nature.com
Engineered natural killer (NK) cells represent a promising option for immune therapy option
due to their immediate availability in allogeneic settings. Severe acute diseases, such as …

[HTML][HTML] Association between HLA-C alleles and COVID-19 severity in a pilot study with a Spanish Mediterranean Caucasian cohort

L Vigón, M Galán, M Torres, AJ Martín-Galiano… - PloS One, 2022 - journals.plos.org
The clinical presentations of COVID-19 may range from an asymptomatic or mild infection to
a critical or fatal disease. Several host factors such as elderly age, male gender, and …

[HTML][HTML] Safety and efficacy of four drug regimens versus standard-of-care for the treatment of symptomatic outpatients with COVID-19: A randomised, open-label, multi …

N Chandiwana, C Kruger, H Johnstone… - …, 2022 - thelancet.com
Background This exploratory study investigated four repurposed anti-infective drug
regimens in outpatients with COVID-19. Methods This phase 2, single centre, randomised …

[HTML][HTML] Understanding host responses to equine encephalitis virus infection: implications for therapeutic development

K Kehn-Hall, SB Bradfute - Expert Review of Anti-infective Therapy, 2022 - Taylor & Francis
Introduction Venezuelan, eastern, and western equine encephalitis viruses (VEEV, EEEV,
and WEEV) are mosquito-borne New World alphaviruses that cause encephalitis in equids …

[HTML][HTML] Rebound COVID-19 and cessation of antiviral treatment for SARS-CoV-2 with Paxlovid and molnupiravir

DV Parums - … science monitor: international medical journal of …, 2022 - ncbi.nlm.nih.gov
One of the most recently described clinical associations with SARS-CoV-2 infection is
rebound COVID-19, which occurs between five and eight days following the cessation of …

AI-Driven Discovery of SARS-CoV-2 Main Protease Fragment-like Inhibitors with Antiviral Activity In Vitro

LC Saramago, MV Santana, BF Gomes… - Journal of Chemical …, 2023 - ACS Publications
SARS-CoV-2 is the causative agent of COVID-19 and is responsible for the current global
pandemic. The viral genome contains 5 major open reading frames of which the largest …

[HTML][HTML] Oral Molnupiravir and Nirmatrelvir/Ritonavir for the Treatment of COVID-19: A Literature Review with a Focus on Real-World Evidence

I Karniadakis, N Mazonakis, C Tsioutis… - Infectious Disease …, 2023 - mdpi.com
Vaccines remain the cornerstone of medical prevention and are highly effective in reducing
the risk of severe disease and death due to coronavirus disease 2019 (COVID-19). In the …

[HTML][HTML] Advances and challenges in using nirmatrelvir and its derivatives against SARS-CoV-2 infection

W Chen, B Liang, X Wu, L Li, C Wang, D Xing - Journal of Pharmaceutical …, 2023 - Elsevier
Abstract On December 22, 2021, the United States Food and Drug Administration approved
the first main protease inhibitor, ie, oral antiviral nirmatrelvir (PF-07321332)/ritonavir …

Nirmatrelvir and ritonavir combination: an antiviral therapy for COVID-19

G Navitha Reddy, A Jogvanshi… - Expert Review of Anti …, 2023 - Taylor & Francis
Introduction The emergence of the Omicron SARS-CoV-2 variant of concern in late
November 2021 presaged yet another stage of the COVID-19 pandemic. Paxlovid, a co …

[HTML][HTML] COVID-19: variants, immunity, and therapeutics for non-hospitalized patients

CYS Lee, JB Suzuki - Biomedicines, 2023 - mdpi.com
The continuing transmission of coronavirus disease 2019 (COVID-19) remains a world-wide
21st-century public health emergency of concern. Severe acute respiratory syndrome …