Serine proteases (SP), including furin, trypsin, and TMPRSS2 cleave the SARS-CoV-2 spike
(S) protein, enabling the virus to enter cells. Here, we show that factor (F) Xa, an SP involved …

Although vaccines are obviously mitigating the COVID-19 pandemic diffusion, efficient
complementary antiviral agents are urgently needed to combat SARS-CoV-2. The viral …

After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies
became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants …

SARS-CoV-2 is currently causing an unprecedented pandemic. While vaccines are
massively deployed, we still lack effective large-scale antiviral therapies. In the quest for …

Most repurposed drugs have proved ineffective for treating COVID-19. We evaluated median
effective and toxic concentrations (EC50, CC50) of 49 drugs, mostly from previous clinical …

ABSTRACT Introduction On 26 November 2021, the World Health Organization's Technical
Advisory Group on SARS-CoV-2 Virus Evolution designated PANGO lineage B. 1.1. 529 a …

Aims The discovery of antiviral substances to respond to COVID‐19 is a global issue,
including the field of drug development based on natural materials. Here, we showed that …

COVID-19 is an infectious disease caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), a novel highly contagious and pathogenic coronavirus that …

Introduction VV116 is a chemically-modified version of the antiviral remdesivir with oral
bioavailability and potent activity against SARS-CoV-2. Areas Covered The optimal …

On the March 11, 2020, the World Health Organization (WHO) declared the outbreak of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a global pandemic …