Identification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19

Y Ma, F Liu, B Li, K Peng, H Zhou, Y Xu, D Qiao… - International …, 2022 - Elsevier
Abstract Background Coronavirus disease 2019 (COVID-19) continues to be a major global
public health challenge, with the emergence of variants of severe acute respiratory …

Фармакологические вещества, проявляющие противовирусную активность в отношении коронавируса SARS-CoV-2

ДА Еникеева, НГ Бондарчук - Экспериментальная и клиническая …, 2022 - ekf.folium.ru
Аннотация Представлены данные о процессе репродукции SARS-CoV-2 и
рассмотрены возможные мишени для фармакологических веществ. Изложены …

The Safety and Efficacy of the Protease Inhibitors Lopinavir/Ritonavir as Monotherapy or Combined with Interferon in COVID-19 Patients

M Kandeel, MA Morsy, HM Abd El-Lateef, M Marzok… - Processes, 2023 - mdpi.com
Enzyme inhibitors are frequently used to treat viral illnesses. Protease inhibitors are a
promising class for combating novel and life-threatening viral infections. This research …

SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

V Kremling, S Falke, Y Fernandez-Garcia, C Ehrt… - bioRxiv, 2024 - biorxiv.org
Non-structural protein 10 (nsp10) and non-structural protein 16 (nsp16) are part of the RNA
synthesis complex, which is crucial for the replication of severe acute respiratory syndrome …

氨溴索治疗新型冠状病毒肺炎的临床效果分析

李力, 张鑫, 戴慕巍, 郑欢伟, 康海燕, 许怡… - 新发传染病电子 …, 2022 - xfcrb2020.com
目的观察盐酸氨溴索治疗新型冠状病毒肺炎的临床疗效和安全性. 方法选取2020 年1–6
月在石家庄市第五医院住院的68 例新型冠状病毒肺炎患者, 随机分为对照组和观察组, 每组34 …

Neumonía adquirida en la comunidad de etiología viral: diversidad, especificidad diagnóstica y factores pronósticos

J Berastegui-Cabrera - 2022 - idus.us.es
La PCR en tiempo real para virus respiratorios ha ampliado el diagnóstico etiológico de la
neumonía adquirida en la comunidad (NAC), pero, a pesar de un trabajo de diagnóstico …

The Concomitant Use of Melatonin and Molnupiravir in the Treatment of COVID-19: Mini Review

IC Haskologlu, E Erdag, S Sayiner… - Bangladesh Journal of …, 2023 - banglajol.info
With the ongoing pandemic declared by the World Health Organization, the number of
hospitalizations and deaths caused by COVID-19 is increasing dramatically. As new variants …

Development and application of consensus hit-calling protocols for the virtual screening of 'undruggable'and difficult drug targets

AT Ton - 2022 - open.library.ubc.ca
Abstract “Undruggable” or “difficult to drug” targets make up most of the human proteome;
these proteins are described as such when it is considered impossible to pharmacologically …

[PDF][PDF] Use of Quercetin for Therapeutic Purposes in COVID-19 Infections: The Opinion of the Geriatrician Doctor

VM Magro - J Mod Biol Drug Discov, 2023 - researchgate.net
The COVID-19 epidemic has put health systems around the world in distress, at the same
time stimulating global research in an attempt to discover new therapeutic strategies against …

Reframing viral infections as acute metabolic disorders: dengue viruses and their dependency on host metabolic pathways

LA St Clair - 2022 - search.proquest.com
Dengue viruses (DENVs) are the etiological agent of the world's most aggressive arthropod-
borne disease. At present, there are no available antivirals against DENVs. This fact …