Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides,
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …

A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and, as such,
provides a semi-selective barrier between the blood and the interstitial space. Compromise …

Rationale: CFTR (cystic fibrosis transmembrane conductance regulator) modulator drugs
restore function to mutant channels in patients with cystic fibrosis (CF) and lead to …

Dysfunction of the vascular angiocrine system is critically involved in regenerative defects
and fibrosis of injured organs. Previous studies have identified various angiocrine factors …

The lymphatic vasculature regulates lung homeostasis through drainage of fluid and
trafficking of immune cells and plays a key role in the response to lung injury in several …

Cell migration regulated by Thrombospondin 2 (THSB2) is important for the development of
pulmonary artery remodeling, but the mechanism by which THBS2-mediated cell migration …

Exertional dyspnea, a key complaint of patients with chronic obstructive pulmonary disease
(COPD), ultimately reflects an increased inspiratory neural drive to breathe. In non …

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS),
present life-threatening conditions characterized by inflammation and endothelial injury …

This study examined the levels of soluble CD146 (sCD146) in plasma samples from patients
with chronic obstructive pulmonary disease (COPD) and assessed the relationship between …

This article provides a comprehensive overview of the latest literature on the diagnostics and
treatment of pulmonary hypertension (PH) associated with interstitial lung disease (ILD) …