An updated review of computer‐aided drug design and its application to COVID‐19

AB Gurung, MA Ali, J Lee, MA Farah… - BioMed research …, 2021 - Wiley Online Library
The recent outbreak of the deadly coronavirus disease 19 (COVID‐19) pandemic poses
serious health concerns around the world. The lack of approved drugs or vaccines continues …

COVID-19: characteristics and therapeutics

R Chilamakuri, S Agarwal - Cells, 2021 - mdpi.com
Novel coronavirus (COVID-19 or 2019-nCoV or SARS-CoV-2), which suddenly emerged in
December 2019 is still haunting the entire human race and has affected not only the …

A review of potential suggested drugs for coronavirus disease (COVID-19) treatment

P Tarighi, S Eftekhari, M Chizari, M Sabernavaei… - European Journal of …, 2021 - Elsevier
The latest pandemic, coronavirus disease-2019 (COVID-19), is associated with high
prevalence and easy transmission, which is expanding globally with no conventional …

Thyroid and COVID-19: a review on pathophysiological, clinical and organizational aspects

G Lisco, A De Tullio, E Jirillo, VA Giagulli… - Journal of …, 2021 - Springer
Background Thyroid dysfunction has been observed in patients with COVID-19, and
endocrinologists are requested to understand this clinical issue. Pandemic-related …

Structure-based optimization of ML300-derived, noncovalent inhibitors targeting the severe acute respiratory syndrome coronavirus 3CL protease (SARS-CoV-2 …

SH Han, CM Goins, T Arya, WJ Shin… - Journal of medicinal …, 2021 - ACS Publications
Starting from the MLPCN probe compound ML300, a structure-based optimization campaign
was initiated against the recent severe acute respiratory syndrome coronavirus (SARS-CoV …

Oral antiviral treatments for COVID-19: opportunities and challenges

L Rahmah, SO Abarikwu, AG Arero, M Essouma… - Pharmacological …, 2022 - Springer
The use of antiviral COVID-19 medications can successfully inhibit SARS-CoV-2 replication
and prevent disease progression to a more severe form. However, the timing of antiviral …

Curcumin inhibits in vitro SARS-CoV-2 infection in Vero E6 cells through multiple antiviral mechanisms

D Marín-Palma, JH Tabares-Guevara… - Molecules, 2021 - mdpi.com
Due to the scarcity of therapeutic approaches for COVID-19, we investigated the antiviral
and anti-inflammatory properties of curcumin against SARS-CoV-2 using in vitro models …

[HTML][HTML] Remdesivir efficacy in COVID-19 treatment: a randomized controlled trial

S Abd-Elsalam, M Salama, S Soliman… - The American Journal …, 2022 - ncbi.nlm.nih.gov
To date, no antiviral therapy has shown proven clinical effectiveness in treating patients with
COVID-19. We assessed the efficacy of remdesivir in hospitalized Egyptian patients with …

Coronavirus disease 2019 (COVID-19) pandemic across Africa: current status of vaccinations and implications for the future

OO Ogunleye, B Godman, JO Fadare, S Mudenda… - Vaccines, 2022 - mdpi.com
The introduction of effective vaccines in December 2020 marked a significant step forward in
the global response to COVID-19. Given concerns with access, acceptability, and hesitancy …

[HTML][HTML] A rapid review of recent advances in diagnosis, treatment and vaccination for COVID-19

S Umakanthan, VK Chattu, AV Ranade, D Das… - AIMS Public …, 2021 - ncbi.nlm.nih.gov
COVID-19 is caused by SARS-CoV-2, which originated in Wuhan, Hubei province, Central
China, in December 2019 and since then has spread rapidly, resulting in a severe …