Background Discovery of novel gametocytocidal molecules is a major pharmacological
strategy in the elimination and eradication of malaria. The high patronage of the aqueous …

A series of quinoline-chalcone (E)-1-[3 or 4-(7-chloroquinolin-4-ylamino) phenyl]-3-(phenyl
substituted) prop-2-ene-1-one (4, 5), and quinoline-pyrazoline hybrids 7-Chloro-N-[3 or 4-(4 …

Only chlorpheniramine has so far shown some clinical utility as a chloroquine resistance
reverser. Recent observations, however, that both primaquine and HIV protease inhibitors …

Nature-derived antimalarials might have anticancer potential, yet no systematic reviews exist
on the topic. We screened MEDLINE using an automated algorithm in a high-volume search …

Plants are one of the most important resources for the discovery of new drugs. The potential
of natural compounds as new drug leads is clearly illustrated by the discovery and …

Malaria is a major global threat, that results in more than 2 million deaths each year. The
treatment of malaria is becoming extremely difficult due to the emergence of drug-resistant …

Abstract Background. On 8 October 2008, members of a tour group experienced diarrhea
and vomiting throughout an airplane flight from Boston, Massachusetts, to Los Angeles …

ABSTRACT A series of [(aryl) arylsufanylmethyl] pyridines (AASMP) have been synthesized.
These compounds inhibited hemozoin formation, formed complexes (KD= 12 to 20 μM) with …

Species of Garcinia have been used to combat malaria in traditional African and Asian
medicines, including Ayurveda. In the current study, we have identified antiplasmodial …

Series of bisquinolines 4–15 and bispyrrolo [1, 2a] quinoxalines 16–20 containing various
polyamine linkers were synthesized. The aqueous solubility and distribution coefficient were …