Myelofibrosis (MF) is a myeloproliferative disorder that exhibits considerable biological and
clinical heterogeneity. At the two ends of the disease spectrum are the myelodepletive or …

The progression of ovarian cancer, from cell transformation through invasion of normal
tissue, relies on communication between tumor cells and their adjacent stromal …

Rationale: Dysregulation of cellular metabolism has been shown to participate in several
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …

Uncontrolled extracellular matrix production by fibroblasts in response to tissue injury
contributes to fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF), a progressive …

The aggressive course of pancreatic cancer is believed to reflect its unusually invasive and
metastatic nature, which is associated with epidermal growth factor receptor (EGFR) …

Excessive extracellular matrix production by fibroblasts in response to tissue injury
contributes to fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF). Epithelial …

Macrophage activation, ie, classical M1 and the alternative M2, plays a critical role in many
pathophysiological processes, such as inflammation and tissue injury and repair. Although …

Long noncoding RNA s (lnc RNA s), once thought to be transcriptional noise, have been
recently shown to regulate a variety of biological processes. However, there is not much …

Chronic hypoxia causes pulmonary vascular remodeling leading to pulmonary hypertension
(PH) and right ventricle (RV) hypertrophy. Aberrant expression of microRNA (miRNA) is …

The expression of smooth muscle actin-α (SMA-α) by fibroblasts defines phenotypic
transition to myofibroblasts and is a primary contributor to contractile force generation by …