Accessible summary What is known on the subject? Research indicates many people
accessing mental healthcare have trauma history and often experience re‐traumatization in …

In this review, we focus on prenatal opioid exposure (POE) given the significant concern for
the mental health outcomes of children with parents affected by opioid use disorder (OUD) in …

A number of retrospective studies have demonstrated adverse childhood experiences are
associated with increased vulnerability to substance use disorders, including opioid use …

Introduction Opioid analgesic treatment during surgery entails the risk of persistent use.
Experiences of childhood adversity have been shown to increase opioid reward in …

Early life stress, such as child abuse and neglect, and psychosocial stress in adulthood are
risk factors for psychiatric disorders, including depression and anxiety. Furthermore …

Active vaccination is an effective therapeutic option to reduce the reinforcing effects of
opioids. Several studies showed that chronic stress affects the immune system decreasing …

Objectives Adverse childhood experiences, or early life trauma (ELT), may be a potential risk
factor for opioid use disorders (OUDs) that could be further influenced by depression …

Molecular autism research is evolving toward a biopsychosocial framework that is more
informed by autistic experiences. In this context, research aims are moving away from …

Background: The Four Factor Personality Vulnerability model (Castellanos-Ryan & Conrod,
2012; Conrod, Pihl, et al., 2000) implicates four personality traits in conferring vulnerability to …

Problematic opioid use that emerges in a subset of individuals may be due to pre-existing
disruptions in the biobehavioral mechanisms that regulate drug use. The identity of these …