Relation Between Obesity and Type 2 Diabetes: Evolutionary Insights, Perspectives and Controversies

MK Gupta, G Gouda, R Vadde - Current Obesity Reports, 2024 - Springer
Abstract Purpose of Review Since the mid-twentieth century, obesity and its related
comorbidities, notably insulin resistance (IR) and type 2 diabetes (T2D), have surged …

Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy

N DeForest, Y Wang, Z Zhu, JS Dron… - Nature …, 2024 - nature.com
Insulin resistance causes multiple epidemic metabolic diseases, including type 2 diabetes,
cardiovascular disease, and fatty liver, but is not routinely measured in epidemiological …

Associations of glycosylated hemoglobin, pre-diabetes, and type 2 diabetes with incident lung cancer: A large prospective cohort study

J Hua, H Lin, X Wang, ZM Qian, MG Vaughn… - Diabetes & Metabolic …, 2024 - Elsevier
Background The association of pre-diabetes and type 2 diabetes (T2D) with incident lung
cancer is uncertain, and the incident risk across the glycemic spectrum is unclear. We aimed …

Linear positive association of metabolic score for insulin resistance with stroke risk among American adults: a cross-sectional analysis of National Health and Nutrition …

R Zheng, X Dong, T Wang, H Zhang, Y Zhou… - Journal of Stroke and …, 2024 - Elsevier
Abstract Background Insulin Resistance (IR) is associated with stroke. This study aimed to
investigate the correlation between metabolic score for insulin resistance (METS-IR) level, a …

Novel inflammatory and insulin resistance indices provide a clue in cerebral amyloid angiopathy

H Zhu, Y Wang, L He, H Luo, C Zong, Y Yang… - Scientific Reports, 2024 - nature.com
This study investigated the correlation of newly identified inflammatory and insulin
resistance indices with cerebral amyloid angiopathy (CAA), and explored their potential to …

Associations of Triglycerides and Atherogenic Index of Plasma with Brain Structure in the Middle-Aged and Elderly Adults

X Chen, Y Bao, J Zhao, Z Wang, Q Gao, M Ma, Z Xie… - Nutrients, 2024 - mdpi.com
Triglyceride (TG) and atherogenic index of plasma (AIP) have been acknowledged to be risk
factors for vascular insults, but their impacts on the brain system remain elusive. To fill in …

Exploring blood lipids-immunity associations following HBV vaccination: evidence from a large cross-sectional study

Q Yang, B Li, T Luan, X Wang, B Duan… - Frontiers in Cellular …, 2024 - frontiersin.org
Introduction Serological responses following hepatitis B vaccination are crucial for
preventing hepatitis B (HBV). However, the potential relationship between serum lipid levels …

Pitfalls in performing genome-wide association studies on ratio traits

ZR McCaw, R Dey, H Somineni, D Amar, S Mukherjee… - bioRxiv, 2023 - biorxiv.org
Genome-wide association studies (GWAS) are often performed on ratios composed of a
numerator trait divided by a denominator trait. Examples include body mass index (BMI) and …

Association of the Triglyceride‐Glucose Index With Resistant Hypertension and a Nomogram Model Construction

HT Yang, JK Liu, BQ Liu, Y Yang… - Journal of the American …, 2023 - ahajournals.org
Background Resistant hypertension (RH) remains one of the major risk factors for
cardiovascular disease. This study aims to investigate the association between the …

Relationship between indices of insulin resistance and incident type 2 diabetes mellitus in Chinese adults

Y Qin, Y Qiao, G Yan, D Wang, C Tang - Endocrine, 2024 - Springer
Background Insulin resistance (IR) is a pivotal pathogenesis characteristic of type 2 diabetes
mellitus (T2DM). The current study aimed to explore the association between …