Background The immune cell compartment of the mammalian brain changes dramatically
and peripheral T cells infiltrate the brain parenchyma during normal aging. However, the …

Plasma transfusions are standard treatments to replace missing proteins in people with rare
genetic diseases. Prior studies have demonstrated that heterochronic parabiosis has …

Fibrotic scars appear after spinal cord injury (SCI) and are mainly composed of fibroblasts
and excess extracellular matrix (ECM), including different types of collagen. The temporal …

Cerebrospinal fluid (CSF) is essential for the development and function of the central
nervous system (CNS). However, the brain and its interstitium have largely been thought of …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Single-cell analysis in living humans is essential for understanding disease mechanisms,
but it is impractical in non-regenerative organs, such as the eye and brain, because tissue …

The ovary has a comparatively short functional lifespan compared with other organs, and
genetic and pathological injuries can further shorten its functional life. Thus, preserving …

Aging is considered the main risk factor for many chronic diseases that frequently appear at
advanced ages. However, the inevitability of this process is being questioned by recent …

Abstract Background Choroid plexuses (ChPs) are intraventricular structures mainly
composed by specialized epithelial cells interconnected by tight junctions that establish the …

Loss of cognitive function with age is devastating. EGL-30/GNAQ and G αq signaling
pathways are highly conserved between C. elegans and mammals, and murine Gnaq is …