Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

[HTML][HTML] Recent advances in the application of ultrasound in dairy products: Effect on functional, physical, chemical, microbiological and sensory properties

LM Carrillo-Lopez, IA Garcia-Galicia… - Ultrasonics …, 2021 - Elsevier
Alternative methods for improving traditional food processing have increased in the last
decades. Additionally, the development of novel dairy products is gaining importance due to …

Noninvasive imaging of nanomedicines and nanotheranostics: principles, progress, and prospects

S Kunjachan, J Ehling, G Storm, F Kiessling… - Chemical …, 2015 - ACS Publications
Nanomedicine is defined as “the application of nanotechnology to medicine, including the
use of nanometer-sized carrier materials for facilitating disease diagnosis, disease treatment …

Understanding ultrasound induced sonoporation: definitions and underlying mechanisms

I Lentacker, I De Cock, R Deckers, SC De Smedt… - Advanced drug delivery …, 2014 - Elsevier
In the past two decades, research has underlined the potential of ultrasound and
microbubbles to enhance drug delivery. However, there is less consensus on the …

Molecular machines open cell membranes

V García-López, F Chen, LG Nilewski, G Duret… - Nature, 2017 - nature.com
Beyond the more common chemical delivery strategies, several physical techniques are
used to open the lipid bilayers of cellular membranes. These include using electric and …

State-of-the-art materials for ultrasound-triggered drug delivery

SR Sirsi, MA Borden - Advanced drug delivery reviews, 2014 - Elsevier
Ultrasound is a unique and exciting theranostic modality that can be used to track drug
carriers, trigger drug release and improve drug deposition with high spatial precision. In this …

Activating drugs with sound: mechanisms behind sonodynamic therapy and the role of nanomedicine

V Choi, MA Rajora, G Zheng - Bioconjugate Chemistry, 2020 - ACS Publications
Sonodynamic therapy (SDT) is a promising therapeutic platform for minimally invasive
cancer treatment in which acoustically susceptible drug agents, sonosensitizers, are …

Ultrasound-triggered nitric oxide release platform based on energy transformation for targeted inhibition of pancreatic tumor

K Zhang, H Xu, X Jia, Y Chen, M Ma, L Sun, H Chen - ACS nano, 2016 - ACS Publications
Inspired by considerable application potential in various diseases, nitric oxide (NO) has
gained increasing attention. Nevertheless, current NO release scaffolds suffer from some …

Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery

K Ferrara, R Pollard, M Borden - Annu. Rev. Biomed. Eng., 2007 - annualreviews.org
This review offers a critical analysis of the state of the art of medical microbubbles and their
application in therapeutic delivery and monitoring. When driven by an ultrasonic pulse …

Healing sound: the use of ultrasound in drug delivery and other therapeutic applications

S Mitragotri - Nature reviews Drug discovery, 2005 - nature.com
Ultrasound, which is routinely used for diagnostic imaging applications, is now being
adopted in various drug delivery and other therapeutic applications. Ultrasound has been …