Exosomes: Potential Next-Generation Nanocarriers for the Therapy of Inflammatory Diseases

T Mori, L Giovannelli, AR Bilia, F Margheri - Pharmaceutics, 2023 - mdpi.com
Inflammatory diseases are common pathological processes caused by various acute and
chronic factors, and some of them are autoimmune diseases. Exosomes are fundamental …

The Therapeutic Mechanisms of Mesenchymal Stem Cells in MS—A Review Focusing on Neuroprotective Properties

S Gavasso, T Kråkenes, H Olsen, EC Evjenth… - International Journal of …, 2024 - mdpi.com
In multiple sclerosis (MS), there is a great need for treatment with the ability to suppress
compartmentalized inflammation within the central nervous system (CNS) and to promote …

Survival and maturation of human induced pluripotent stem cell-derived dopaminergic progenitors in the parkinsonian rat brain is enhanced by transplantation in a …

G Comini, R Kelly, S Jarrin, T Patton… - Journal of Neural …, 2024 - iopscience.iop.org
Objective. Although human induced pluripotent stem cell (iPSC)-derived cell replacement for
Parkinson's disease has considerable reparative potential, its full therapeutic benefit is …

Exosomes from Hypoxia-treated Mesenchymal Stem Cells: Promoting Neuroprotection in Ischemic Stroke Through miR-214-3p/PTEN Mechanism

Q Wu, JH Wu, ZY Ye, W She, WJ Peng, HX Zhang… - Molecular …, 2024 - Springer
Stroke stands as the second leading cause of death globally, surpassed only by ischemic
heart disease. It accounts for 9% of total worldwide deaths. Given the swiftly evolving …

Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice

Y Fu, Y Zhang, R Liu, M Xu, J Xie, X Zhang… - Journal of …, 2024 - Springer
Background The transplantation of exosomes derived from human adipose-derived
mesenchymal stem cells (hADSCs) has emerged as a prospective cellular-free therapeutic …

Dual impacts of mesenchymal stem cell-derived exosomes on cancer cells: unravelling complex interactions

B Jahangiri, M Khalaj-Kondori, E Asadollahi… - Journal of Cell …, 2023 - Springer
Mesenchymal stem cells (MSCs) are multipotent, self-renewing stromal cells found in a
variety of adult tissues. MSCs possess a remarkable ability to migrate towards tumor sites …

Logic “AND Gate Circuit” Based Mussel Inspired Polydopamine Nanocomposite as Bioactive Antioxidant for Management of Oxidative Stress and Neurogenesis in …

S Garg, A Jana, J Khan, S Gupta, R Roy… - … Applied Materials & …, 2024 - ACS Publications
In the intricate landscape of Traumatic Brain Injury (TBI), the management of TBI remains a
challenging task due to the extremely complex pathophysiological conditions and excessive …

Engineered exosomes enriched with select microRNAs amplify their therapeutic efficacy for traumatic brain injury and stroke

L Chen, Y Xiong, M Chopp, Y Zhang - Frontiers in Cellular …, 2024 - frontiersin.org
Traumatic brain injury (TBI) and stroke stand as prominent causes of global disability and
mortality. Treatment strategies for stroke and TBI are shifting from targeting neuroprotection …

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Y Qiu, G Lu, N Li, Y Hu, H Tan, C Jiang - Frontiers in Immunology, 2024 - frontiersin.org
Gastric cancer (GC) is a malignant neoplasm originating from the epithelial cells of the
gastric mucosa. The pathogenesis of GC is intricately linked to the tumor microenvironment …

[HTML][HTML] Modulating the release of bioactive molecules of human mesenchymal stromal cell secretome: Heparinization of hyaluronic acid-based hydrogels

FS Palumbo, C Fiorica, AP Carreca, G Iannolo… - International Journal of …, 2024 - Elsevier
An amine derivative of hyaluronic acid (HA) was crosslinked to obtain a 3D dried sponge.
The sponge was subsequently rehydrated using secretome from human mesenchymal …