We introduce a user-friendly tool for risk gene, cell type, and drug prioritization for complex
traits: GCDPipe. It uses gene-level GWAS-derived data and gene expression data to train a …

There is an urgent and unmet need to advance our ability to translate genetic studies of
psychiatric disorders into clinically actionable information, which could transform diagnostics …

Rac1 and RhoA are among the most widely studied small GTPases. The classic dogma
surrounding their biology has largely focused on their activity as an “on/off switch” of sorts …

Schizophrenia is a severe and heritable neuropsychiatric disorder, which arises due to a
combination of common genetic variation, rare loss of function variation, and copy number …

With the continued deluge of results from genome-wide association and functional genomic
studies, it has become increasingly imperative to quickly combine and visualize different …

Recent genome-wide association studies (GWAS) and whole-exome sequencing of
neuropsychiatric disorders, especially schizophrenia, have identified a plethora of common …

Genome-wide (GWAS) and copy number variant (CNV) association studies have
reproducibly identified numerous risk alleles associated with bipolar disorder (BD), major …

Genome-wide association studies (GWAS) of mood disorders in large case-control cohorts
have identified numerous risk loci, yet pathophysiological mechanisms remain elusive …

Schizophrenia is a highly heritable psychiatric disorder with a complex genetic risk
architecture that reflects the additive impact of hundreds of risk variants. While many …

Schizophrenia exhibits up to 80% heritability. A number of genome wide association studies
(GWAS) have repeatedly shown common variants in voltage-gated calcium (Ca v) channel …