Objective The SCHEMA consortium has identified 10 genes in which protein-truncating
variants (PTVs) confer a substantial risk of schizophrenia. This study aimed to determine …

Schizophrenia is a chronic mental illness that is amongst the most debilitating conditions
encountered in medical practice. A recent landmark schizophrenia study of the protein …

Genetics have nominated many schizophrenia risk genes that lack functional interpretation.
To empower such interpretation, we executed interaction proteomics for six risk genes in …

Schizophrenia is a disabling neuropsychiatric disorder of adulthood onset with high
heritability. Worldwide collaborations have identified an association of~ 270 common loci …

Genome-wide association studies have successfully identified hundreds of genomic regions
associated with schizophrenia (SCZ). Subsequent fine-mapping of the strongest association …

An important issue pertinent to the analysis of sequence data to detect association between
rare variants in a gene and a given phenotype is the ability to annotate nonsynonymous …

Obsessive-compulsive disorder (OCD) is a complex, multifactorial disorder with onset in
either childhood or early adulthood. Lifetime prevalence has been estimated to be around …

Abstract Whole Exome Sequencing (WES) studies provide important insights into the
genetic architecture of serious mental illness (SMI). Genes that are central to the shared …

Autism spectrum disorders (ASD), Tourette syndrome (TS), and attention-deficit/hyperactivity
disorder (ADHD) display strong male sex bias, due to a combination of genetic and …

Schizophrenia (SCZ) is a severe chronic psychiatric illness with heterogeneous symptoms.
However, the pathogenesis of SCZ is unclear, and the number of well-defined SCZ risk …