Why and how we age are 2 intertwined questions that have fascinated scientists for many
decades. However, attempts to answer these questions remain compartmentalized …

Circulating plasma proteins play key roles in human health and can potentially be used to
measure biological age, allowing risk prediction for age-related diseases, multimorbidity and …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Background Metformin, a first-line medication for type 2 diabetes, might also have a
protective effect against ageing-related diseases, but so far little experimental evidence is …

Abstract Introduction Native American communities suffer disproportionately from elevated
metal exposures and increased risk for cardiovascular diseases and diabetes. DNA …

Background Biological age is a measure of health that offers insights into ageing. The
existing age clocks, although valuable, often trade off accuracy and interpretability. We …

Diverse individuals age at different rates and display variable susceptibilities to tissue aging,
functional decline and aging-related diseases. Centenarians, exemplifying extreme …

Identifying the clinical implications and modifiable and unmodifiable factors of aging
requires the measurement of biological age (BA) and age gap. Leveraging the biomedical …

To test the hypothesis that early-life adversity accelerates the pace of biological aging, we
analyzed data from the Dutch Hunger Winter Families Study (DHWFS, N= 951). DHWFS is a …

Technical advancements over the past two decades have enabled the measurement of the
panoply of molecules of cells and tissues including transcriptomes, epigenomes …