Beyond mere prognostication, optimal biomarkers of aging provide insights into qualitative
and quantitative features of biological aging and might, therefore, offer useful information for …

Most membrane proteins are modified by covalent addition of complex sugars through N-
and O-glycosylation. Unlike proteins, glycans do not typically adopt specific secondary …

Objectives Individuals with more education are at lower risk of developing multiple, different
age-related diseases than their less-educated peers. A reason for this might be that …

Despite the prominence of the weathering hypothesis as a mechanism underlying racialized
inequities in morbidity and mortality, the life course social and economic determinants of …

Epigenetic age is an emerging marker of health that is highly predictive of disease and
mortality risk. There is a lack of evidence on whether lifestyle changes are associated with …

XAI is a rapidly progressing field of machine learning, aiming to unravel the predictions of
complex models. XAI is especially required in sensitive applications, eg in health care, when …

Inferring the chronological and biological age of individuals is fundamental to population
ecology and our understanding of ageing itself, its evolution, and the biological processes …

Epigenetic modifications are chemical modifications that affect gene expression without
altering DNA sequences. In particular, epigenetic chemical modifications can occur on …

Accurately measuring biological age is crucial for improving healthcare for the elderly
population. However, the complexity of aging biology poses challenges in how to robustly …

Computational models that measure biological age and aging rate regardless of
chronological age are called aging clocks. The underlying counting mechanisms of the …