Biomarkers of ageing: Current state‐of‐art, challenges, and opportunities

R Chen, Y Wang, S Zhang, G Bulloch… - MedComm–Future …, 2023 - Wiley Online Library
Given the unprecedented phenomenon of population ageing, studies have increasing
captured the heterogeneity within the ageing process. In this context, the concept of …

ClockBase: a comprehensive platform for biological age profiling in human and mouse

K Ying, A Tyshkovskiy, A Trapp, H Liu, M Moqri… - bioRxiv, 2023 - biorxiv.org
Aging represents the greatest risk factor for chronic diseases and mortality, but to
understand it we need the ability to measure biological age. In recent years, many machine …

A unified framework for evolutionary genetic and physiological theories of aging

JF Lemaître, J Moorad, JM Gaillard, AA Maklakov… - Plos …, 2024 - journals.plos.org
Why and how we age are 2 intertwined questions that have fascinated scientists for many
decades. However, attempts to answer these questions remain compartmentalized …

An explainable AI framework for interpretable biological age

W Qiu, H Chen, M Kaeberlein, SI Lee - medRxiv, 2022 - medrxiv.org
Background An individual's biological age is a measurement of health status and provides a
mechanistic understanding of aging. Age clocks estimate a biological age of an individual …

Diet, pace of biological aging, and risk of dementia in the Framingham Heart Study

A Thomas, CP Ryan, A Caspi, Z Liu… - Annals of …, 2024 - Wiley Online Library
Objective People who eat healthier diets are less likely to develop dementia, but the
biological mechanism of this protection is not well understood. We tested the hypothesis that …

Association of Air Pollution with a Urinary Biomarker of Biological Aging and Effect Modification by Vitamin K in the FLEMENGHO Prospective Population Study

DS Martens, DW An, YL Yu, BS Chori… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: A recently developed urinary peptidomics biological aging clock can be used
to study accelerated human aging. From 1990 to 2019, exposure to airborne particulate …

Application of AI in biological age prediction

D Meng, S Zhang, Y Huang, K Mao, JDJ Han - Current Opinion in Structural …, 2024 - Elsevier
The development of anti-aging interventions requires quantitative measurement of biological
age. Machine learning models, known as “aging clocks,” are built by leveraging diverse …

AI analysis of chest radiographs as a biomarker of biological age

PS Babyn, SJ Adams - The Lancet Healthy Longevity, 2023 - thelancet.com
Chronological age is the greatest risk factor for most common chronic diseases. However,
molecular and cellular age-related decline varies substantively between individuals …

Considerations for reproducible omics in aging research

PP Singh, BA Benayoun - Nature Aging, 2023 - nature.com
Technical advancements over the past two decades have enabled the measurement of the
panoply of molecules of cells and tissues including transcriptomes, epigenomes …

Better care for older patients with complex multimorbidity and frailty: a call to action

L Ferrucci, R Kohanski - The Lancet Healthy Longevity, 2022 - thelancet.com
Over the past few decades, the ageing of the population has led to profound changes in
fundamental aspects of how our society is organised. These include changes in family …