[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering

JR Tribble, F Hui, H Quintero, S El Hajji, K Bell… - Molecular aspects of …, 2023 - Elsevier
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects

A Boccaccini, D Cavaterra, C Carnevale… - Molecular Aspects of …, 2023 - Elsevier
In the last years, neuroprotective therapies have attracted the researcher interests as
modern and challenging approach for the treatment of neurodegenerative diseases, aimed …

Methodological appraisal of phase 3 clinical trials in geographic atrophy

M Biarnés, X Garrell-Salat, A Gómez-Benlloch… - Biomedicines, 2023 - mdpi.com
Geographic atrophy (GA) secondary to age-related macular degeneration is a common
cause of blindness worldwide. Given the recent approval of the first therapy for GA …

Discernibility of the interdigitation zone (IZ), a potential optical coherence tomography (OCT) biomarker for visual dysfunction in aging

A Berlin, E Matney, SG Jones, ME Clark… - Current Eye …, 2023 - Taylor & Francis
Purpose Photoreceptor (PR) outer segments, retinal pigment epithelium apical processes,
and inter-PR matrix contribute to the interdigitation zone (IZ) of optical coherence …

[PDF][PDF] The Extraordinary Phenotypic and Genetic Variability of Retinal and Macular Degenerations: The Relevance to Therapeutic Developments

I Audo, M Nassisi, C Zeitz, JA Sahel - Cold Spring Harb. Perspect …, 2023 - cshlpress.com
Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of
rare conditions leading to various degrees of visual handicap and to progressive blindness …

Clinical Pharmacology Perspective on Development of Adeno‐Associated Virus Vector‐Based Retina Gene Therapy

JL Ford, E Karatza, H Mody… - Clinical …, 2024 - Wiley Online Library
Adeno‐associated virus (AAV) vector‐based gene therapy is an innovative modality being
increasingly investigated to treat diseases by modifying or replacing defective genes or …

Retinal Imaging Findings in Inherited Retinal Diseases

G Corradetti, A Verma, J Tojjar, L Almidani… - Journal of Clinical …, 2024 - mdpi.com
Inherited retinal diseases (IRDs) represent one of the major causes of progressive and
irreversible vision loss in the working-age population. Over the last few decades, advances …

A Golden Hour and Golden Opportunity for β-Cell Preservation

C Evans-Molina, RA Oram - Diabetes, 2024 - Am Diabetes Assoc
For the last several decades, most clinical trials and attempts to slow or stop autoimmune-
mediated destruction of b-cells during type 1 diabetes (T1D) have focused on administration …

[HTML][HTML] Functional assessments of the ocular circulation

R Heitmar, D Link, K Kotliar, D Schmidl, S Klee - Frontiers in Medicine, 2023 - frontiersin.org
In recent years, ocular vascular functional imaging has gained importance due to the
increasing availability of new methods such as optical coherence tomography angiography …

[HTML][HTML] Agreement, repeatability, and reproducibility of quantitative retinal layer assessment using swept-source and spectral-domain optical coherence tomography …

H Hou, MK Durbin, N El-Nimri, JL Fischer… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Purpose To evaluate the agreement and precision of retinal thickness measurements
obtained using swept-source optical coherence tomography (SS-OCT) and spectral-domain …