[HTML][HTML] Navigating multi-scale cancer systems biology towards model-driven clinical oncology and its applications in personalized therapeutics

MN Gondal, SU Chaudhary - Frontiers in Oncology, 2021 - frontiersin.org
Rapid advancements in high-throughput omics technologies and experimental protocols
have led to the generation of vast amounts of scale-specific biomolecular data on cancer …

Imidazolium ionic liquids as effective antiseptics and disinfectants against drug resistant S. aureus: In silico and in vitro studies

D Hodyna, V Kovalishyn, I Semenyuta… - … Biology and Chemistry, 2018 - Elsevier
Аbstract This paper describes Quantitative Structure-Activity Relationships (QSAR) studies,
molecular docking and in vitro antibacterial activity of several potent imidazolium-based …

Modeling cellular noise underlying heterogeneous cell responses in the epidermal growth factor signaling pathway

K Iwamoto, Y Shindo, K Takahashi - PLoS computational biology, 2016 - journals.plos.org
Cellular heterogeneity, which plays an essential role in biological phenomena, such as drug
resistance and migration, is considered to arise from intrinsic (ie, reaction kinetics) and …

High methylation of the 4-aminobutyrate aminotransferase gene predicts a poor prognosis in patients with myelodysplastic syndrome

G Zhao, N Li, S Li, W Wu… - … Journal of Oncology, 2019 - spandidos-publications.com
In our previous study, the 4‑aminobutyrate aminotransferase (ABAT) gene was screened
and selected as a target gene that may affect the prognosis of myelodysplastic syndrome …

Correlation between the protein expression levels of A‐kinase anchor protein95, p‐retinoblastoma (Ser780), cyclin D2/3, and cyclin E2 in esophageal cancer tissues

S Wang, K Wang, Z Deng, Z Jiang… - Asia‐Pacific Journal …, 2019 - Wiley Online Library
Aim This study aimed to investigate the correlation between the expression of A‐kinase
anchor protein95 (AKAP95), p‐retinoblastoma (phosphorylated Rb, p‐Rb), cyclin D2, cyclin …

Caspases interplay with kinases and phosphatases to determine cell fate

S Akbari-Birgani, M Khademy… - European Journal of …, 2019 - Elsevier
Cellular differentiation is one of the critical processes in the life of multicellular organisms. In
this phenomenon, a non-specialized cell is converted to a specialized one with its own …

A study on the predictability of acute lymphoblastic leukaemia response to treatment using a hybrid oncosimulator

E Ouzounoglou, E Kolokotroni, M Stanulla… - Interface …, 2018 - royalsocietypublishing.org
Efficient use of Virtual Physiological Human (VPH)-type models for personalized treatment
response prediction purposes requires a precise model parameterization. In the case where …

Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized Therapeutics

MN Gondal, SU Chaudhary - bioRxiv, 2021 - biorxiv.org
Rapid advancements in high-throughput omics technologies and experimental protocols
have led to the generation of vast amounts of biomolecular data on cancer that now …

[PDF][PDF] Μέθοδοι Βιοπληροφορικής, Υπολογιστικής Συστημικής Βιολογίας και Μηχανικής Μάθησης, Εφαρμοσμένες στην In Silico Ογκολογία

Ε Ουζούνογλου - 2018 - dspace.lib.ntua.gr
Περίληψη Στα πλαίσια της παρούσας διατριβής μελετήθηκαν οι επιστημονικοί τομείς της
Βιοπληροφορικής, της Υπολογιστικής Συστημικής Βιολογίας και της Μηχανικής Μάθησης με …