The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …
devastating consequences. While the medical community has gained insight into the …
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds
to acute respiratory distress syndrome and death. Three highly pathogenic human …
to acute respiratory distress syndrome and death. Three highly pathogenic human …
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
JD Domizio, MF Gulen, F Saidoune, VV Thacker… - Nature, 2022 - nature.com
COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung
pathology and extrapulmonary complications,. Type I interferons (IFNs) have an essential …
pathology and extrapulmonary complications,. Type I interferons (IFNs) have an essential …
[HTML][HTML] Inflammasome activation in infected macrophages drives COVID-19 pathology
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine
production, viral RNA and a sustained interferon (IFN) response, all of which are …
production, viral RNA and a sustained interferon (IFN) response, all of which are …
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas
Infection-related diabetes can arise as a result of virus-associated β-cell destruction. Clinical
data suggest that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
data suggest that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19
F D'Agnillo, KA Walters, Y Xiao, ZM Sheng… - Science translational …, 2021 - science.org
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is characterized by respiratory distress, multiorgan …
coronavirus 2 (SARS-CoV-2), is characterized by respiratory distress, multiorgan …
[HTML][HTML] The spatial landscape of lung pathology during COVID-19 progression
Recent studies have provided insights into the pathology of and immune response to COVID-
19,,,,,,–. However, a thorough investigation of the interplay between infected cells and the …
19,,,,,,–. However, a thorough investigation of the interplay between infected cells and the …
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
GJ Martínez-Colón, K Ratnasiri, H Chen… - Science Translational …, 2022 - science.org
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection
The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between
antiviral and inflammatory features. SARS-CoV-2–specific T cells in individuals who clear …
antiviral and inflammatory features. SARS-CoV-2–specific T cells in individuals who clear …
[HTML][HTML] Persistence of SARS CoV-2 S1 protein in CD16+ monocytes in post-acute sequelae of COVID-19 (PASC) up to 15 months post-infection
BK Patterson, EB Francisco, R Yogendra… - Frontiers in …, 2022 - frontiersin.org
The recent COVID-19 pandemic is a treatment challenge in the acute infection stage but the
recognition of chronic COVID-19 symptoms termed post-acute sequelae SARS-CoV-2 …
recognition of chronic COVID-19 symptoms termed post-acute sequelae SARS-CoV-2 …