Introduction Understanding normative patterns of change in kidney function over the life
course may allow targeting of early interventions to slow or prevent the onset of kidney …

Measures of epigenetic aging derived from DNA methylation (DNAm) have enabled the
assessment of biological aging in new populations and cohorts. In the present study, we …

In our recent transcriptomic meta-analysis, we used random forest machine learning to
accurately predict age in human blood, bone, brain, heart, and retina tissues given gene …

Biological aging of human organ systems reflects the interplay of age, chronic disease,
lifestyle and genetic risk. Using longitudinal organ imaging and physiological phenotypes …

Female adolescent voice change (FAVC) is characterized by objectively measurable
developments in both physiological and acoustical aspects of voice. Despite these …

Objectives: The Dunedin Multidisciplinary Health and Development Study provides a unique
opportunity to document the progression of ear health and hearing ability within the same …

We investigated the strength of the association between baseline epigenetic age, everyday
discrimination, and trajectories of chronic health conditions (CHCs) across 3 study waves …

Physical frailty is a syndrome that typically manifests in later life, although the pathogenic
process causing physical frailty likely begins decades earlier. To date, few studies have …

Biological aging is near-ubiquitous in the animal kingdom, but its timing and pace vary
between individuals and over lifespans. Prospective, individual-based studies of wild …

Abstract Background and Objectives “Successful aging” as defined in Rowe & Kahn's model
aims to include the major domains of aging under a single overarching concept. From here …