Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …

Human T cells have a diverse T‐cell receptor (TCR) repertoire that endows them with the
ability to identify and defend against a broad spectrum of antigens. The universe of possible …

A system for programmable export of RNA molecules from living cells would enable both
non-destructive monitoring of cell dynamics and engineering of cells capable of delivering …

The delivery of genetic cargo remains one of the largest obstacles to the successful
translation of experimental therapies, in large part due to the absence of targetable delivery …

Viruses and virally derived particles have the intrinsic capacity to deliver molecules to cells,
but the difficulty of readily altering cell-type selectivity has hindered their use for therapeutic …

Cell-type-specific in vivo delivery of genome editing molecules is the next breakthrough that
will drive biological discovery and transform the field of cell and gene therapy. Here, we …

The cGAS-STING signaling pathway has emerged as a promising target for immunotherapy
development. Here, we introduce a light-sensitive optogenetic device for control of the …

Neoantigen immunogenicity prediction is a burgeoning field with vast potential; however, the
shortage of high-quality data and biases in current datasets limit model generalizability …

Certain bacterial strains from the microbiome induce a potent, antigen-specific T cell
response,,,–. However, the specificity of microbiome-induced T cells has not been explored …

Adult tissue-specific stem cells play a dominant role in tissue homeostasis and regeneration.
Various in vivo markers of adult tissue-specific stem cells have been increasingly reported …