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Liver transplantation offers live-saving therapy for patients with complications of cirrhosis
and stage T2 hepatocellular carcinoma. The demand for organs far outstrips the supply, and …

Recent human decedent model studies, and compassionate xenograft use have explored
the promise of porcine organs for human transplantation. To proceed to human studies, a …

Synthetic genomics is the construction of viruses, bacteria, and eukaryotic cells with
synthetic genomes. It involves two basic processes: synthesis of complete genomes or …

Background Cross-species immunological incompatibilities have hampered pig-to-human
xenotransplantation, but porcine genome engineering recently enabled the first successful …

A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …

Methods| In this case series, persons aged 18 years or older declared brain dead whose
families provided informed consent for study participation were eligible for study entry after …

Pigs are valuable large animal models for biomedical and genetic research, but insights into
the tissue-and cell-type-specific transcriptome and heterogeneity remain limited. By …

Organ allotransplantation has now reached an impassable ceiling inherent to the limited
supply of human donor organs. In the United States, there are currently over 100,000 …

Animal models of human diseases play a critical role in medical research. Pigs are
anatomically and physiologically more like humans than are small rodents such as mice …