SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …

Klebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution,
insertion, or deletion of amino acid sequence compared to wild bla KPC type, have reduced …

Surveillance studies have shown that OXA-48-like carbapenemases are the most common
carbapenemases in Enterobacterales in certain regions of the world and are being …

Modern medicine is threatened by the rising tide of antimicrobial resistance, especially
among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β …

Carbapenemase-producing Enterobacteriaceae (CPE) contribute significantly to the global
public health threat of antimicrobial resistance. OXA-48 and its variants are unique …

Antimicrobial resistance (AMR) is a global public-health emergency, which threatens the
advances made by modern medical care over the past century. The World Health …

The first reports of carbapenem resistance in Enterobacteriaceae isolates occurred in the
early 1990s. Researchers published the first report of an isolate that produced Klebsiella …

Objectives To investigate the increase in the rates of OXA-48-like-producing isolates during
3 years of global surveillance. Methods Among 55?> 162 Enterobacterales isolates, 354 …

We have adopted an open bioinformatics ecosystem to address the challenges of
bioinformatics implementation in public health laboratories (PHLs). Bioinformatics …

Carbapenem-resistant Enterobacterales (CRE) are a growing public health concern due to
resistance to multiple antibiotics and potential to cause health care-associated infections …