New findings necessitate a paradigm shift in our understanding of acute pancreatitis. Intra-
acinar trypsinogen activation leads to early pancreatic injury, but the inflammatory response …

Oxidative stress is considered to be an important regulator of the pathogenesis of acute
pancreatitis. Reactive oxygen species (ROS) regulate the activation of inflammatory …

Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may
lead to a severe systemic inflammatory response. A key event in pancreatic damage is the …

Hypertriglyceridemia is associated with a number of severe diseases such as acute
pancreatitis and coronary artery disease. In severe hypertriglyceridemia (SHTG …

Acute pancreatitis (AP) is characterized by early activation of intra‐acinar proteases followed
by acinar cell death and inflammation. Cellular oxidative stress is a key mechanism …

Rosmarinic acid (RA) is a potential herbal medicine and has received considerable attention
due to its strong antioxidant properties. The aim of this study is to investigate the impact of …

Objective Innate and adaptive immunity may contribute to gland dysfunction in patients with
primary Sjögren's syndrome (p SS). The P 2 X 7 receptor (P 2 X 7 R)–NLRP 3 …

Disruption of Ca 2+ homeostasis can lead to severe damage of the pancreas, resulting in
premature activation of digestive enzymes, vacuolisation and necrotic cell death, features …

Background & aims There is no consensus on relationship between total cholesterol levels
and incidence of severe acute pancreatitis (SAP). The aim of this study was to investigate …

Oxidative stress has been shown to play an important role in the pathogenesis of acute
pancreatitis (AP). Antioxidants, alone or in combination with conventional therapy, should …