Genetic models of human and mouse dendritic cell development and function
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …
numerous shared characteristics between mice and humans. Human counterparts of mouse …
STAT3 signaling in immunity
EJ Hillmer, H Zhang, HS Li, SS Watowich - Cytokine & growth factor …, 2016 - Elsevier
The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
Granulocyte-monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes
A Yáñez, SG Coetzee, A Olsson, DE Muench… - Immunity, 2017 - cell.com
Granulocyte-monocyte progenitors (GMPs) and monocyte-dendritic cell progenitors (MDPs)
produce monocytes during homeostasis and in response to increased demand during …
produce monocytes during homeostasis and in response to increased demand during …
Targeting janus kinases and signal transducer and activator of transcription 3 to treat inflammation, fibrosis, and cancer: rationale, progress, and caution
U Bharadwaj, MM Kasembeli, P Robinson… - Pharmacological …, 2020 - ASPET
Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells
PF Rodrigues, L Alberti-Servera, A Eremin… - Nature …, 2018 - nature.com
Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high
amounts of type 1 interferons in response to viral infections. Whereas conventional dendritic …
amounts of type 1 interferons in response to viral infections. Whereas conventional dendritic …
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune
responses according to peripheral cues. After four decades of research, we now know that …
responses according to peripheral cues. After four decades of research, we now know that …
Development of monocytes, macrophages, and dendritic cells
Monocytes and macrophages are critical effectors and regulators of inflammation and the
innate immune response, the immediate arm of the immune system. Dendritic cells initiate …
innate immune response, the immediate arm of the immune system. Dendritic cells initiate …
Deciphering the transcriptional network of the dendritic cell lineage
Although much progress has been made in the understanding of the ontogeny and function
of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and …
of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and …
Transcriptional control of dendritic cell development
TL Murphy, GE Grajales-Reyes, X Wu… - Annual review of …, 2016 - annualreviews.org
The dendritic cells (DCs) of the immune system function in innate and adaptive responses
by directing activity of various effector cells rather than serving as effectors themselves. DCs …
by directing activity of various effector cells rather than serving as effectors themselves. DCs …
Decisions about dendritic cells: past, present, and future
RM Steinman - Annual review of immunology, 2012 - annualreviews.org
A properly functioning adaptive immune system signifies the best features of life. It is diverse
beyond compare, tolerant without fail, and capable of behaving appropriately with a myriad …
beyond compare, tolerant without fail, and capable of behaving appropriately with a myriad …