[HTML][HTML] Integration of immune cells in organs-on-chips: a tutorial

L Van Os, B Engelhardt, OT Guenat - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Viral and bacterial infections continue to pose significant challenges for numerous
individuals globally. To develop novel therapies to combat infections, more insight into the …

[HTML][HTML] Experimental models to study end-organ morbidity in sleep apnea: lessons learned and future directions

R Farré, I Almendros, MÁ Martínez-García… - International Journal of …, 2022 - mdpi.com
Sleep apnea (SA) is a very prevalent sleep breathing disorder mainly characterized by
intermittent hypoxemia and sleep fragmentation, with ensuing systemic inflammation …

[HTML][HTML] Cancer-on-chip: a 3D model for the study of the tumor microenvironment

E Cauli, MA Polidoro, S Marzorati, C Bernardi… - Journal of Biological …, 2023 - Springer
The approval of anticancer therapeutic strategies is still slowed down by the lack of models
able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro …

[HTML][HTML] Harnessing three-dimensional (3D) cell culture models for pulmonary infections: State of the art and future directions

DD Shah, NR Raghani, MR Chorawala, S Singh… - Naunyn-Schmiedeberg's …, 2023 - Springer
Pulmonary infections have been a leading etiology of morbidity and mortality worldwide.
Upper and lower respiratory tract infections have multifactorial causes, which include …

[HTML][HTML] Current possibilities and future opportunities provided by three-dimensional lung ECM-derived hydrogels

M Nizamoglu, JK Burgess - Frontiers in Pharmacology, 2023 - frontiersin.org
Disruption of the complex interplay between cells and extracellular matrix (ECM), the
scaffold that provides support, biochemical and biomechanical cues, is emerging as a key …

Biocompatible, Antibacterial, and Stable Deep Eutectic Solvent-Based Ionic Gel Multimodal Sensors for Healthcare Applications

JY Yang, A Kumar, MO Shaikh, SH Huang… - … Applied Materials & …, 2023 - ACS Publications
In this study, we investigated a novel approach to fabricate multifunctional ionic gel sensors
by using deep eutectic solvents (DESs) as replacements for water. When two distinct DESs …

[HTML][HTML] Lung extracellular matrix hydrogels-derived vesicles contribute to epithelial lung repair

A Ulldemolins, A Jurado, C Herranz-Diez, N Gavara… - Polymers, 2022 - mdpi.com
The use of physiomimetic decellularized extracellular matrix-derived hydrogels is attracting
interest since they can modulate the therapeutic capacity of numerous cell types, including …

[HTML][HTML] What is the need and why is it time for innovative models for understanding lung repair and regeneration?

DJ Weiss - Frontiers in Pharmacology, 2023 - frontiersin.org
Advances in tissue engineering continue at a rapid pace and have provided novel
methodologies and insights into normal cell and tissue homeostasis, disease pathogenesis …

[HTML][HTML] Fast cycling of intermittent hypoxia in a physiomimetic 3D environment: A novel tool for the study of the parenchymal effects of sleep apnea

A Jurado, A Ulldemolins, H Lluís, X Gasull… - Frontiers in …, 2023 - frontiersin.org
Background: Patients with obstructive sleep apnea (OSA) experience recurrent hypoxemic
events with a frequency sometimes exceeding 60 events/h. These episodic events induce …

OPEN ACCESS EDITED BY

RL Heise, NT Awatade, CM Magin… - … 3D models for …, 2024 - books.google.com
Background: Different asthma phenotypes are driven by molecular endotypes. A Th1-high
phenotype is linked to severe, therapy-refractory asthma, subclinical infections and …