Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID‐19

M Manik, RK Singh - Journal of medical virology, 2022 - Wiley Online Library
Balanced immune regulation is crucial for recognizing an invading pathogen, its killing, and
elimination. Toll‐like receptors (TLRs) are the key regulators of the innate immune system. It …

[HTML][HTML] Hyperinflammatory response in COVID-19: a systematic review

MJA Silva, LR Ribeiro, MIM Gouveia, BR Marcelino… - Viruses, 2023 - mdpi.com
COVID-19 is a multisystemic disease caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The immunopathogenic conditions of the hyperinflammatory …

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene

N Magusali, AC Graham, TM Piers, P Panichnantakul… - Brain, 2021 - academic.oup.com
Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …

Association between IL-6 and severe disease and mortality in COVID-19 disease: a systematic review and meta-analysis

X Liu, H Wang, S Shi, J Xiao - Postgraduate medical journal, 2022 - academic.oup.com
Abstract Background So far, SARS-CoV-2 is the seventh coronavirus found to infect humans
and cause disease with quite a strong infectivity. Patients diagnosed as severe or critical …

Cerebrospinal fluid in COVID-19 neurological complications: Neuroaxonal damage, anti-SARS-Cov2 antibodies but no evidence of cytokine storm

MA Garcia, PV Barreras, A Lewis, G Pinilla… - Journal of the …, 2021 - Elsevier
Objective To study in cerebrospinal fluid (CSF) of COVID-19 subjects if a “cytokine storm” or
neuroinflammation are implicated in pathogenesis of neurological complications. Methods …

Pathophysiology, diagnosis, and management of neuroinflammation in covid-19

RL Brown, L Benjamin, MP Lunn, T Bharucha… - bmj, 2023 - bmj.com
Although neurological complications of SARS-CoV-2 infection are relatively rare, their
potential long term morbidity and mortality have a significant impact, given the large …

[PDF][PDF] C-reactive protein a promising biomarker of COVID-19 severity

M Fazal - Korean Journal of Clinical Laboratory Science, 2021 - researchgate.net
In December 2019, several pneumonia cases of unexplained etiology erupted in Wuhan
city, China [1]. The causative pathogen now recognized as a novel coronavirus (nCoV) …

[HTML][HTML] Strategies to DAMPen COVID-19-mediated lung and systemic inflammation and vascular injury

C Bime, NG Casanova, J Nikolich-Zugich, KS Knox… - Translational …, 2021 - Elsevier
ABSTRACT Approximately 15%-20% of patients infected with SARS-CoV-2 coronavirus
(COVID-19) progress beyond mild and self-limited disease to require supplemental oxygen …

[HTML][HTML] Ocular transmissibility of COVID-19: possibilities and perspectives

G Davis, K Li, FG Thankam, DR Wilson… - Molecular and Cellular …, 2022 - Springer
Since the initial outbreak of coronavirus disease 2019 (COVID-19), extensive research has
emerged from across the globe to understand the pathophysiology of this novel coronavirus …

[HTML][HTML] Elevated interleukin (IL)-6 as a predictor of disease severity among Covid-19 patients: a prospective cohort study

B Nikkhoo, M Mohammadi, S Hasani, N Sigari… - BMC Infectious …, 2023 - Springer
Background accompanied to the spreading of coronavirus disease 2019 (Covid-19) in the
world, identifying factors related to the severity of the disease is one of the interests of …