The extracellular signal-regulated kinase (ERK) plays a central role in the signaling
cascades of cell growth. Here, we show that stochastic ERK activity pulses regulate cell …

E-cadherin is a cell–cell adhesion protein fulfilling a prominent role in epithelial
differentiation. Data from model systems suggest that E-cadherin is a potent invasion/tumor …

Background The E‐cadherin–catenin complex plays a crucial role in epithelial cell–cell
adhesion and in the maintenance of tissue architecture. Perturbation in the expression or …

Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal
transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts …

J. Clin. Invest. 109: 987–991 (2002). DOI: 10.1172/JCI200215429. repress its promoter.
These include snail, E12/E47, and SIP1, which bind to the CDH1 promoter, inhibit E-cad …

E-cadherin and the associated catenin complex have been recognised as performing a key
role in cell adhesion. Loss of cell adhesion is seen as a key step in the cascade leading to …

Invasion causes cancer malignancy. We review recent data about cellular and molecular
mechanisms of invasion, focusing on cross-talk between the invaders and the host. Cancer …

Mammalian cellular responses to hypoxia include adaptive metabolic changes and a G 1
cell cycle arrest. Although transcriptional regulation of metabolic genes by the hypoxia …

It has long been appreciated that proliferation of many cells is inhibited by density, a
phenomenon that is often attributed to cell–cell contact. The basic properties of this …

Confluent endothelial cells respond poorly to the proliferative signals of VEGF. Comparing
isogenic endothelial cells differing for vascular endothelial cadherin (VE-cadherin) …