Oxidative stress and hyper-inflammation as major drivers of severe COVID-19 and long COVID: implications for the benefit of high-dose intravenous vitamin C

C Vollbracht, K Kraft - Frontiers in Pharmacology, 2022 - frontiersin.org
Oxidative stress is a pivotal point in the pathophysiology of COVID-19 and presumably also
in Long-COVID. Inflammation and oxidative stress are mutually reinforcing each other, thus …

Vitamin C supplementation for the treatment of COVID-19: a systematic review and meta-analysis

M Olczak-Pruc, D Swieczkowski, JR Ladny, M Pruc… - Nutrients, 2022 - mdpi.com
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, caused by the
severe respiratory syndrome coronavirus 2 (SARS-CoV-2), millions of people have died …

Parenteral vitamin C in patients with severe infection: a systematic review

A Agarwal, J Basmaji, SM Fernando, FZ Ge… - NEJM …, 2022 - evidence.nejm.org
Background Inflammation and oxidative damage caused by severe infections may be
attenuated by vitamin C. Methods We conducted a systematic review of randomized …

History of scurvy and use of vitamin C in critical illness: A narrative review

E Dresen, ZY Lee, A Hill, Q Notz… - Nutrition in Clinical …, 2023 - Wiley Online Library
In 1747, an important milestone in the history of clinical research was set, as the Scottish
surgeon James Lind conducted the first randomized controlled trial. Lind was interested in …

Impact of intravenous vitamin C as a monotherapy on mortality risk in critically ill patients: a meta-analysis of randomized controlled trials with trial sequential analysis

KC Hung, MH Chuang, JY Chen, CW Hsu… - Frontiers in …, 2023 - frontiersin.org
Background This meta-analysis aimed at investigating the pooled evidence regarding the
effects of intravenous vitamin C (IVVC) on mortality rate in critically ill patients. Methods …

Micronutrient perspective on COVID-19: Umbrella review and reanalysis of meta-analyses

Y Xie, J Xu, D Zhou, M Guo, M Zhang… - Critical reviews in …, 2024 - Taylor & Francis
Introduction Micronutrients are clinically important in managing COVID-19, and numerous
studies have been conducted, but inconsistent findings exist. Objective To explore the …

The effect of macronutrient and micronutrient supplements on COVID-19: an umbrella review

SA SeyedAlinaghi, R Shahidi, H Mojdeganlou… - Journal of Health …, 2024 - Springer
Background and aims A healthy diet play an important role in the prevention and even
treatment of various diseases. Proper nutrition plays an important role in boosting of immune …

COVID-19, the gut, and nutritional implications

MG Bell, R Ganesh, SL Bonnes - Current Nutrition Reports, 2023 - Springer
Abstract Purpose of Review Our goal is to provide the most recent and accurate scientific
evidence available regarding COVID-19's interaction with the human gut and the role of …

The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prevention and Management of COVID-19 and Long-COVID: An …

A Sinopoli, A Sciurti, C Isonne, MM Santoro… - Nutrients, 2024 - mdpi.com
This review aims to evaluate the efficacy of any vitamin administration (s) in preventing and
managing COVID-19 and/or long-COVID. Databases were searched up to May 2023 to …

Nutrition and immunity: lessons from coronavirus disease-2019

PC Calder - Proceedings of the Nutrition Society, 2023 - cambridge.org
This review will provide an overview of the immune system and then describe the effects of
frailty, obesity, specific micronutrients and the gut microbiota on immunity and susceptibility …