Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …

The Hypoxia Inducible Factor 1 (HIF-1) plays a major role in the cellular response to hypoxia
by regulating the expression of many genes involved in adaptive processes that allow cell …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that acts as a regulator of
oxygen (O2) homeostasis in metazoan species by binding to hypoxia response elements …

Oxygen, which is necessary for sustaining energy metabolism, is consumed in many
biochemical reactions in eukaryotes. When the oxygen supply is insufficient for maintaining …

Hypoxia increases patient treatment resistance and favors cancer progression. Nanozymes
have received unprecedented attention in alleviating hypoxia via catalase (CAT)-mimicking …

Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry,
but the control points are unknown. In pulmonary arterial hypertension (PAH), a disease …

Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that
nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. NM1 directly …

Angiogenesis is hijacked by cancer to support tumor growth. RNA modifications such as N6-
methyladenosine (m6A) can regulate several aspects of cancer, including angiogenesis …

Cholesterol biosynthesis is a highly regulated, oxygen-dependent pathway, vital for cell
membrane integrity and growth. In fungi, the dependency on oxygen for sterol production …

The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both …