The emergence and spread of new HIV-1 variants pose a challenge for the effectiveness of
antiretrovirals (ARV) targeting Pol proteins. During viral evolution, non-synonymous …

The persistence of infected T cells harbouring intact HIV proviruses is the barrier to the
eradication of HIV. This reservoir is stable over long periods of time despite antiretroviral …

Despite the critical role of epitope presentation for immune recognition, we still lack a
comprehensive definition of HIV peptides presented by HIV-infected cells. Here we identified …

Abstract Introduction In Mexico, HIV genotyping is performed in people living with HIV
(PLWH) failing their first-line antiretroviral (ARV) regimen; it is not routinely done for all …

Amino acid preferences at a protein site depend on the role of this site in protein function
and structure as well as on external constraints. All these factors can change in the course of …

Maturation of human immunodeficiency virus type 1 (HIV-1) particles is a key step for viral
infectivity. This process can be blocked using maturation inhibitors (MIs) that affect the …

The ability of human immunodeficiency virus type 1 (HIV-1) to transduce nondividing cells is
key to infecting terminally differentiated macrophages, which can serve as a long-term …

Background HIV-1 subtype C demonstrates several biological properties distinct from other
viral subtypes. One such variation is the duplication of PTAP motif in p6 Gag. PTAP motif is a …

Motivation Commonly, protease inhibitor failure is characterized by the development of
multiple protease resistance mutations (PRMs). While the impact of PRMs on therapy failure …

Ankyrins are cellular repeat proteins, which can be genetically modified to randomize amino-
acid residues located at defined positions in each repeat unit, and thus create a potential …