Specific Interaction of DARPin with HIV-1 CANTD Disturbs the Distribution of Gag, RNA Packaging, and Tetraspanin Remodelling in the Membrane
S Moonmuang, R Maniratanachote, P Chetprayoon… - Viruses, 2022 - mdpi.com
A designed repeat scaffold protein (AnkGAG1D4) recognizing the human immunodeficiency
virus-1 (HIV-1) capsid (CA) was formerly established with antiviral assembly. Here, we …
virus-1 (HIV-1) capsid (CA) was formerly established with antiviral assembly. Here, we …
Specific inter-domain interactions stabilize a compact HIV-1 Gag conformation
HIV-1 Gag is a large multidomain poly-protein with flexible unstructured linkers connecting
its globular subdomains. It is compact when in solution but assumes an extended …
its globular subdomains. It is compact when in solution but assumes an extended …
Preferential targeting of conserved gag regions after vaccination with a heterologous DNA prime-modified vaccinia virus Ankara boost HIV-1 vaccine regimen
A Bauer, L Podola, P Mann, M Missanga… - Journal of …, 2017 - Am Soc Microbiol
Prime-boost vaccination strategies against HIV-1 often include multiple variants for a given
immunogen for better coverage of the extensive viral diversity. To study the immunologic …
immunogen for better coverage of the extensive viral diversity. To study the immunologic …
Broad-spectrum antiviral activity of an ankyrin repeat protein on viral assembly against chimeric NL4-3 viruses carrying Gag/PR derived from circulating strains among …
S Sakkhachornphop, S Hadpech, T Wisitponchai… - Viruses, 2018 - mdpi.com
Certain proteins have demonstrated proficient human immunodeficiency virus (HIV-1) life
cycle disturbance. Recently, the ankyrin repeat protein targeting the HIV-1 capsid …
cycle disturbance. Recently, the ankyrin repeat protein targeting the HIV-1 capsid …
A new ensemble coevolution system for detecting HIV-1 protein coevolution
Background A key challenge in the field of HIV-1 protein evolution is the identification of
coevolving amino acids at the molecular level. In the past decades, many sequence-based …
coevolving amino acids at the molecular level. In the past decades, many sequence-based …
Potential Associations of Mutations within the HIV-1 Env and Gag Genes Conferring Protease Inhibitor (PI) Drug Resistance
NF Maphumulo, ML Gordon - Microbiology Research, 2021 - mdpi.com
An increasing number of patients in Africa are experiencing virological failure on a second-
line antiretroviral protease inhibitor (PI)-containing regimen, even without resistance …
line antiretroviral protease inhibitor (PI)-containing regimen, even without resistance …
Insights into HIV-1 capsid inhibitors in preclinical and early clinical development as antiretroviral agents
M Cevik, C Orkin - Expert Opinion on Investigational Drugs, 2019 - Taylor & Francis
Almost 30 years after the discovery of the first approved antiretroviral (ARV) agent
Zidovidine, more than 25 additional agents in five drug classes have been discovered …
Zidovidine, more than 25 additional agents in five drug classes have been discovered …
Dimeric ankyrin with inverted module promotes bifunctional property in capturing capsid to impede HIV-1 replication
O Juntit, K Sornsuwan, T Wisitponchai… - International Journal of …, 2023 - mdpi.com
Several anti-HIV scaffolds have been proposed as complementary treatments to highly
active antiretroviral therapy. AnkGAG1D4, a designed ankyrin repeat protein, formerly …
active antiretroviral therapy. AnkGAG1D4, a designed ankyrin repeat protein, formerly …
HIV-1 Gag C-terminal amino acid substitutions emerging under selective pressure of protease inhibitors in patient populations infected with different HIV-1 subtypes
HIV-1 Gag amino acid substitutions associated with protease inhibitor (PI) treatment have
mainly been reported in subtype B, while information on other subtypes is scarce. Using …
mainly been reported in subtype B, while information on other subtypes is scarce. Using …
Computational Design of Epitope-Enriched HIV-1 Gag Antigens with Preserved Structure and Function for Induction of Broad CD8+ T Cell Responses
B Asbach, JP Meier, M Pfeifer, J Köstler, R Wagner - Scientific Reports, 2018 - nature.com
The partially protective phenotype observed in HIV-infected long-term-non-progressors is
often associated with certain HLA alleles, thus indicating that cytotoxic T lymphocyte (CTL) …
often associated with certain HLA alleles, thus indicating that cytotoxic T lymphocyte (CTL) …