Structure of FIV capsid C-terminal domain demonstrates lentiviral evasion of genetic fragility by coevolved substitutions
Viruses use a strategy of high mutational rates to adapt to environmental and therapeutic
pressures, circumventing the deleterious effects of random single-point mutations by …
pressures, circumventing the deleterious effects of random single-point mutations by …
Anti-virus reagents targeting the capsid protein assembly
DY Fu, YR Xue, X Yu, Y Wu - Journal of Materials Chemistry B, 2019 - pubs.rsc.org
Anti-viral therapy has made remarkable strides in improving the quality of life of infected
individuals over the past few decades. However, the emergence of adverse side effects and …
individuals over the past few decades. However, the emergence of adverse side effects and …
Microplate-based assay for identifying small molecules that bind a specific intersubunit interface within the assembled HIV-1 capsid
UD Halambage, JP Wong, BJ Melancon… - Antimicrobial Agents …, 2015 - Am Soc Microbiol
Despite the availability of> 30 effective drugs for managing HIV-1 infection, no current
therapy is curative, and long-term management is challenging owing to the emergence and …
therapy is curative, and long-term management is challenging owing to the emergence and …
[PDF][PDF] Transcriptional Targeting of Dendritic Cells as a New Therapeutic Vaccine against HIV-1
A Strack - 2024 - scholar.archive.org
Abstract According to the World Health Organisation in 2021, more than 38 million people
were living with the Human Immunodeficiency Virus (HIV). While antiretroviral therapy (ART) …
were living with the Human Immunodeficiency Virus (HIV). While antiretroviral therapy (ART) …
Uracil derivatives as HIV-1 capsid protein inhibitors: design, in silico, in vitro and cytotoxicity studies
D Ramesh, AK Mohanty, A De, BG Vijayakumar… - RSC …, 2022 - pubs.rsc.org
A series of novel uracil derivatives such as bispyrimidine dione and tetrapyrimidine dione
derivatives were designed based on the existing four-point pharmacophore model as …
derivatives were designed based on the existing four-point pharmacophore model as …
Selection analyses of paired HIV-1 gag and gp41 sequences obtained before and after antiretroviral therapy
Most HIV-1-infected individuals with virological failure on a pharmacologically-boosted
protease inhibitor (PI) regimen do not develop PI-resistance protease mutations. One …
protease inhibitor (PI) regimen do not develop PI-resistance protease mutations. One …
Peptide inhibitors for the inhibition of hiv capsid
U Neogi, A Sonnerborg, K Singh, TP Quinn… - US Patent App. 17 …, 2022 - Google Patents
US20220306690A1 - Peptide inhibitors for the inhibition of hiv capsid - Google Patents
US20220306690A1 - Peptide inhibitors for the inhibition of hiv capsid - Google Patents …
US20220306690A1 - Peptide inhibitors for the inhibition of hiv capsid - Google Patents …
[PDF][PDF] Learning ancestral polytrees
Causal polytrees are singly connected causal models and they are frequently applied in
practice. However, in various applications, many variables remain unobserved and causal …
practice. However, in various applications, many variables remain unobserved and causal …
Příprava a charakterizace vazebných proteinů mimikujících epitopy protilátek neutralizujících virus HIV-1
J Šulc - 2021 - dspace.cuni.cz
Tři dekády trvající pandemie viru HIV stála život již desítky milionu lidí, další desítky milionů
se s touto nevyléčitelnou chorobou potýkají do dnešního dne. Současné neúspěchy ve …
se s touto nevyléčitelnou chorobou potýkají do dnešního dne. Současné neúspěchy ve …
[PDF][PDF] Data Descriptor: Selection analyses of paired HIV-1 gag and gp41 sequences obtained before and after antiretroviral therapy
Methods Gag and gp41 sequences of paired samples obtained before and after PI or NNRTI
therapy The sequences described in our previous manuscript were obtained from HIV-1 …
therapy The sequences described in our previous manuscript were obtained from HIV-1 …