Investigating the role of Gag in protease inhibitor susceptibility amongst West African HIV-1 subtypes

RWP Datir - 2020 - discovery.ucl.ac.uk
HIV-1 Gag contributes to susceptibility of protease inhibitors (PIs) in the absence of known
resistance mutations in the protease gene. For the majority of HIV-infected patients …

[PDF][PDF] p-di-pyrrole Benzene Derivatives-A New Class of Highly Active HIV-1 CA Inhibitors

NBS Ghosh, A Bag - Acta Scientific Pharmaceutical Sciences (ISSN …, 2021 - academia.edu
Background: In spite of so many FDA approved HIV drugs, HIV infections and deaths are
increasing across the glob. Thus, HIV research is still important and challenging. Finding of …

[图书][B] An investigation into the binding mode of novel small molecule HIV-1 capsid (CA) protein inhibitors

JM Maurancy - 2020 - search.proquest.com
Among the HIV-1 capsid inhibitors, PF-74 is by far the most characterized. It has a
multimodal mechanism of action, preventing the uncoating of the capsid core and …

[PDF][PDF] Novel concepts for the treatment of HSV-2 and other enveloped viruses

F Krüger - 2019 - oparu.uni-ulm.de
Until now, there are many antiviral drugs on the market but only selected viruses are
targeted. In many cases, drugs are often invented in the aftermath of an outbreak and only …

Examination of the Role of HIV-1 Capsid Sequence on Virus Infectivity, Host Protein Interactions, and Capsid Uncoating

DK Fischer - 2019 - search.proquest.com
Human immunodeficiency virus type 1 (HIV-1) infection persists for life, requiring the regular
administration of antiretroviral therapy (ART) to suppress viral replication. Poorly tolerated …

Supercharged Assembly: A Broad-Spectrum Mechanism of Action for Drugs that Undermine Controlled HIV-1 Viral Capsid Formation

AJ Pak, JMA Grime, A Yu, GA Voth - bioRxiv, 2019 - biorxiv.org
The early and late stages of human immunodeficiency virus (HIV) replication are
orchestrated by the capsid (CA) protein, which self-assembles into a conical protein shell …

Relevancia del antígeno Gag para el desarrollo de candidatos vacunales contra el VIH-1

AB Fresneda-Mora, I Rodríguez-Alonso… - Biotecnología …, 2019 - medigraphic.com
Gag es una de las proteínas más conservadas del VIH-1. Se ha demostrado que las
regiones invariables de este antígeno son críticas para la capacidad replicativa viral y la …

Variabilidad natural en los sitios de procesamiento viral y en posiciones asociadas a resistencias antirretrovirales de la proteasa, retrotranscriptasa e integrasa en las …

T Llácer Delicado - 2018 - docta.ucm.es
TERESA LLÁCER DELICADO ha realizado bajo su dirección en el Laboratorio de
Epidemiología Molecular del VIH-1 del Servicio de Microbiología del Hospital Universitario …

[PDF][PDF] EVALUATION OF RESPONSE OF IMMUNE PARAMETERS IN HIV SUBJECTS ON ANTIRETROVIRAL THERAPY IN PORT HARCOURT

CR Oparaodu, CK Wachukwu… - European Journal of …, 2018 - researchgate.net
This cross sectional study was aimed at evaluating the response of immune parameters in
HIV positive subjects on antiretroviral therapy in Port Harcourt, Rivers State, Nigeria. A total …

[引用][C] The HIV-1 gag and protease: exploring the coevolving nature and structural implications of complex drug resistance mutational patterns in subtype C.

V Marie - 2019