Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Cannabis has a long history of anecdotal medicinal use and limited licensed medicinal use.
Until recently, alleged clinical effects from anecdotal reports and the use of licensed …

The functional maturation and preservation of hepatic cells derived from human induced
pluripotent stem cells (hiPSCs) are essential to personalized in vitro drug screening and …

Genes encoding cytochrome P450 enzymes (CYPs) are extremely polymorphic and multiple
CYP variants constitute clinically relevant biomarkers for the guidance of drug selection and …

This paper explores the transformative role of pharmacists in integrating pharmacogenomics
into clinical practice. Pharmacogenomics, the study of genetic influences on drug response …

Therapeutic drug monitoring (TDM), ie, the quantification of serum or plasma concentrations
of medications for dose optimization, has proven a valuable tool for the patient-matched …

Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

Interindividual variability in drug response is a major clinical problem. Polymedication and
genetic polymorphisms modulating drug-metabolising enzyme activities (cytochromes P450 …

The maintenance of terminally differentiated cells, especially hepatocytes, in vitro has
proven challenging. Here we demonstrated the long-term in vitro maintenance of primary …

Obtaining fully functional cell types is a major challenge for drug discovery and regenerative
medicine. Currently, a fundamental solution to this key problem is still lacking. Here, we …