Cardiac fibrosis: the fibroblast awakens
Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …
The good and the bad collagens of fibrosis–their role in signaling and organ function
Usually the dense extracellular structure in fibrotic tissues is described as extracellular
matrix (ECM) or simply as collagen. However, fibrosis is not just fibrosis, which is already …
matrix (ECM) or simply as collagen. However, fibrosis is not just fibrosis, which is already …
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is
both a cause and consequence of fibroblast activation. However, the molecular mechanisms …
both a cause and consequence of fibroblast activation. However, the molecular mechanisms …
Glycolytic reprogramming in myofibroblast differentiation and lung fibrosis
Rationale: Dysregulation of cellular metabolism has been shown to participate in several
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
P Ramachandran, A Pellicoro… - Proceedings of the …, 2012 - National Acad Sciences
Although macrophages are widely recognized to have a profibrotic role in inflammation, we
have used a highly tractable CCl4-induced model of reversible hepatic fibrosis to identify …
have used a highly tractable CCl4-induced model of reversible hepatic fibrosis to identify …
[HTML][HTML] Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …
The myofibroblast matrix: implications for tissue repair and fibrosis
Myofibroblasts, and the extracellular matrix (ECM) in which they reside, are critical
components of wound healing and fibrosis. The ECM, traditionally viewed as the structural …
components of wound healing and fibrosis. The ECM, traditionally viewed as the structural …
Overview of the immune response
DD Chaplin - Journal of allergy and clinical immunology, 2010 - Elsevier
The immune system has evolved to protect the host from a universe of pathogenic microbes
that are themselves constantly evolving. The immune system also helps the host eliminate …
that are themselves constantly evolving. The immune system also helps the host eliminate …
Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for In Vitro Investigation
AJ Booth, R Hadley, AM Cornett, AA Dreffs… - American journal of …, 2012 - atsjournals.org
Rationale: Extracellular matrix (ECM) is a dynamic tissue that contributes to organ integrity
and function, and its regulation of cell phenotype is a major aspect of cell biology. However …
and function, and its regulation of cell phenotype is a major aspect of cell biology. However …
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
G Liu, A Friggeri, Y Yang, J Milosevic, Q Ding… - Journal of Experimental …, 2010 - rupress.org
Uncontrolled extracellular matrix production by fibroblasts in response to tissue injury
contributes to fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF), a progressive …
contributes to fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF), a progressive …