Brain edema is one of the most devastating consequences of ischemic stroke. Malignant
cerebral edema is the main reason accounting for the high mortality rate of large …

Drug development for ischemic stroke is challenging as evidenced by the paucity of
therapeutics that have advanced beyond a phase III trial. There are many reasons for this …

Inflammatory disease is often associated with an increased incidence of venous
thromboembolism in affected patients, although in most instances, the mechanistic basis for …

In order to study effects of macrophage-derived inflammatory mediators associated with
systemic inflammation on brain endothelial cells, we have established a co-culture system …

3K3A-Activated Protein C (APC) is a recombinant variant of the physiological anticoagulant
APC with cytoprotective properties and reduced bleeding risks. We studied the potential use …

Cell-based therapies hold great promise for brain repair after stroke. While accumulating
evidence confirms the preclinical and clinical benefits of cell therapies, the underlying …

Epilepsy is one of the most common neurologic disorders that is characterized by recurrent
seizures, and depending on the type of seizure, it could lead to a severe outcome. Epilepsy's …

The blood-brain barrier is composed of microvascular endothelial cells, immune cells, and
astrocytes that work in concert with the coagulation cascade to control inflammation and …

Abstract Background Activated protein C (APC) has anticoagulant and cytoprotective cell-
signaling activities, which often require protease-activated receptor (PAR) 1 and PAR3 and …

Single-Cell RNA sequencing reveals changes in cell population in Alzheimer's disease (AD)
model 5xFAD (5x Familial AD mutation) versus wild type (WT) mice. The returned …