Antimalarial drug discovery: Progress and approaches
Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …
overcome emerging drug resistance, whilst considering safety and improving dosing …
[HTML][HTML] Plasmodium falciparum resistance to artemisinin-based combination therapies
Highlights•Mutant K13-mediated artemisinin resistance involves reduced hemoglobin
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …
[HTML][HTML] Safety and efficacy of a monoclonal antibody against malaria in Mali
K Kayentao, A Ongoiba, AC Preston… - … England Journal of …, 2022 - Mass Medical Soc
Background CIS43LS is a monoclonal antibody that was shown to protect against controlled
Plasmodium falciparum infection in a phase 1 clinical trial. Whether a monoclonal antibody …
Plasmodium falciparum infection in a phase 1 clinical trial. Whether a monoclonal antibody …
[图书][B] Stratégie de riposte face à la résistance aux antipaludiques en Afrique
World Health Organization - 2023 - books.google.com
La Stratégie de riposte face à la résistance aux antipaludiques en Afrique est un document
technique de sensibilisation qui se fonde sur les bases factuelles les plus solides dont on …
technique de sensibilisation qui se fonde sur les bases factuelles les plus solides dont on …
Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa
PJ Rosenthal, V Asua, MD Conrad - Nature Reviews Microbiology, 2024 - nature.com
Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …
important infectious diseases in the world. Standard treatment for uncomplicated P …
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness
Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now
threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we …
threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we …
[图书][B] Strong systems and sound investments: evidence on and key insights into accelerating progress on sanitation, drinking-water and hygiene: UN-water global …
World Health Organization - 2023 - books.google.com
Page 1 UN WATER World Health Organization STRONG SYSTEMS AND SOUND
INVESTMENTS EVIDENCE ON AND KEY INSIGHTS INTO ACCELERATING PROGRESS ON …
INVESTMENTS EVIDENCE ON AND KEY INSIGHTS INTO ACCELERATING PROGRESS ON …
Antimalarial artesunate–mefloquine versus praziquantel in African children with schistosomiasis: an open-label, randomized controlled trial
Schistosomiasis treatment entirely relies on a single drug, praziquantel, prompting research
into alternative therapeutics. Here we evaluated the efficacy and safety of the antimalarial …
into alternative therapeutics. Here we evaluated the efficacy and safety of the antimalarial …
Pre-gelation staining expansion microscopy for visualisation of the Plasmodium liver stage
K Atchou, BM Berger, V Heussler… - Journal of cell …, 2023 - journals.biologists.com
Fluorescence and light microscopy are important tools in the history of natural science.
However, the resolution of microscopes is limited by the diffraction of light. One possible …
However, the resolution of microscopes is limited by the diffraction of light. One possible …
The emergence of artemisinin partial resistance in Africa: how do we respond?
PJ Rosenthal, V Asua, JA Bailey… - The Lancet Infectious …, 2024 - thelancet.com
Malaria remains one of the most important infectious diseases in the world, with the greatest
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …